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    ribE 6,7-dimethyl-8-ribityllumazine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946453, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ribE
    Official Full Name
    6,7-dimethyl-8-ribityllumazine synthase
    Primary source
    ECOCYC:EG11322
    Locus tag
    b0415
    See related
    ASAP:ABE-0001444
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0409; nusIII; ribH; ybaF
    Summary
    The ribE gene encodes lumazine synthase, an enzyme that catalyzes the penultimate step in the riboflavin biosynthesis pathway. [More information is available at EcoCyc: EG11322].
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    Genomic context

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    Sequence:
    NC_000913.3 (434647..435117)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene NrdR transcriptional repressor Neighboring gene fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase Neighboring gene transcription antitermination protein NusB Neighboring gene thiamine monophosphate kinase Neighboring gene phosphatidylglycerophosphatase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli. Vervoort J, et al. Antimicrob Agents Chemother, 2014 Dec. PMID 25246406, Free PMC Article
    2. A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications. Zhang Y, et al. J Org Chem, 2008 Apr 4. PMID 18331058
    3. Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli. Mörtl S, et al. J Biol Chem, 1996 Dec 27. PMID 8969176
    4. Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli. Lee CY, et al. J Biochem Mol Biol, 2007 Mar 31. PMID 17394775
    5. Alterations in chromosomal genes nfsA, nfsB, and ribE are associated with nitrofurantoin resistance in Escherichia coli from the United Kingdom. Wan Y, et al. Microb Genom, 2021 Dec. PMID 34860151, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alterations in chromosomal genes nfsA, nfsB, and ribE are associated with nitrofurantoin resistance in Escherichia coli from the United Kingdom.
      Title: Alterations in chromosomal genes nfsA, nfsB, and ribE are associated with nitrofurantoin resistance in Escherichia coli from the United Kingdom.
    2. An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli.
      Title: An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli.
    3. In this study, the binding properties of wild type as well as two mutated proteins of N-terminal domain of riboflavin synthase with various ligands were tested.
      Title: Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 6,7-dimethyl-8-ribityllumazine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6,7-dimethyl-8-ribityllumazine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 6,7-dimethyl-8-ribityllumazine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in riboflavin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within riboflavin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of riboflavin synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    6,7-dimethyl-8-ribityllumazine synthase
    NP_414949.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      434647..435117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414949.1 6,7-dimethyl-8-ribityllumazine synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414949.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C1D681
      Conserved Domains (1) summary
      PRK00061
      Location:1 → 155
      ribH; 6,7-dimethyl-8-ribityllumazine synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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