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    mdlA ABC transporter family protein MdlA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945092, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mdlA
    Official Full Name
    ABC transporter family protein MdlA
    Primary source
    ECOCYC:G6248
    Locus tag
    b0448
    See related
    ASAP:ABE-0001555
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0442; mdl
    Summary
    Although MdlAB are similar to multidrug exporters, no overexpression resistances were found. mdlA and mdlB were fused by a frameshift mutation or sequencing error in the original report. mdlA and mdlB were fused by a frameshift mutation or sequencing error in the original report. [More information is available at EcoGene: EG11622]. MdlA and MdlB are uncharacterized members of the ABC superfamily of transporters . [More information is available at EcoCyc: G6248].
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    Genomic context

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    Sequence:
    NC_000913.3 (468871..470643)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene HMP-PP phosphatase Neighboring gene DNA-binding transcriptional activator DecR Neighboring gene ABC transporter family protein MdlB Neighboring gene nitrogen regulatory protein PII-2 Neighboring gene ammonium transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and organization of the abc and mdl genes of Escherichia coli: relationship to eukaryotic multidrug resistance. Allikmets R, et al. Gene, 1993 Dec 22. PMID 7904973
    2. Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. Kobayashi N, et al. J Bacteriol, 2001 Oct. PMID 11544226, Free PMC Article
    3. Defining a rob regulon in Escherichia coli by using transposon mutagenesis. Bennik MH, et al. J Bacteriol, 2000 Jul. PMID 10850996, Free PMC Article
    4. Analysis of a complete library of putative drug transporter genes in Escherichia coli. Nishino K, et al. J Bacteriol, 2001 Oct. PMID 11566977, Free PMC Article
    5. The Escherichia coli ATP-binding cassette (ABC) proteins. Linton KJ, et al. Mol Microbiol, 1998 Apr. PMID 9593292

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic export from cell IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ABC transporter family protein MdlA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      468871..470643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414982.1 ABC transporter family protein MdlA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414982.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EFL6
      Conserved Domains (1) summary
      PRK10789
      Location:22 → 590
      PRK10789; SmdA family multidrug ABC transporter permease/ATP-binding protein
    Nucleotide Protein
    Heading Accession and Version

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