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    mntR DNA-binding transcriptional dual regulator MntR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945437, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mntR
    Official Full Name
    DNA-binding transcriptional dual regulator MntR
    Primary source
    ECOCYC:G6420
    Locus tag
    b0817
    See related
    ASAP:ABE-0002793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0807; ybiQ
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    Genomic context

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    Sequence:
    NC_000913.3 (853183..853650)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoethanolamine transferase OpgE Neighboring gene ncRNA Neighboring gene small protein MntS Neighboring gene putative transporter YbiR Neighboring gene L,D-transpeptidase LdtB Neighboring gene putative ATP-binding protein YbiT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the manganese transport regulatory protein from Escherichia coli. Tanaka T, et al. Proteins, 2009 Nov 15. PMID 19701940
    2. The Escherichia coli K-12 MntR miniregulon includes dps, which encodes the major stationary-phase DNA-binding protein. Yamamoto K, et al. J Bacteriol, 2011 Mar. PMID 21239586, Free PMC Article
    3. Regulation of Salmonella enterica serovar Typhimurium mntH transcription by H(2)O(2), Fe(2+), and Mn(2+). Kehres DG, et al. J Bacteriol, 2002 Jun. PMID 12029030, Free PMC Article
    4. Dual repression by Fe(2+)-Fur and Mn(2+)-MntR of the mntH gene, encoding an NRAMP-like Mn(2+) transporter in Escherichia coli. Patzer SI, et al. J Bacteriol, 2001 Aug. PMID 11466284, Free PMC Article
    5. Emerging themes in manganese transport, biochemistry and pathogenesis in bacteria. Kehres DG, et al. FEMS Microbiol Rev, 2003 Jun. PMID 12829271

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This work defines two MntR-regulated new proteins, MntS and MntP, involved in manganese homeostasis and suggests mechanisms for their action.
      Title: The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis.
    2. Unexpectedly, the authors found that dps expression is directly repressed by Mn(2+)-MntR.
      Title: The Escherichia coli K-12 MntR miniregulon includes dps, which encodes the major stationary-phase DNA-binding protein.
    3. Crystal structure of the manganese transport regulatory protein from Escherichia coli
      Title: Crystal structure of the manganese transport regulatory protein from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator MntR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      853183..853650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415338.1 DNA-binding transcriptional dual regulator MntR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415338.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6BJK3
      Conserved Domains (1) summary
      PRK11050
      Location:4 → 155
      PRK11050; manganese-binding transcriptional regulator MntR
    Nucleotide Protein
    Heading Accession and Version

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