U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ddpX D-alanyl-D-alanine dipeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945532, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ddpX
    Official Full Name
    D-alanyl-D-alanine dipeptidase
    Primary source
    ECOCYC:G6782
    Locus tag
    b1488
    See related
    ASAP:ABE-0004960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1482; vanX; yddT
    Summary
    RpoS regulon. [More information is available at EcoGene: EG13791]. VanX is a D-Ala-D-Ala dipeptidase, which catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide required for wild-type peptidoglycan biosynthesis . [More information is available at EcoCyc: G6782].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1562495..1563076, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative D,D-dipeptide ABC transporter membrane subunit DdpC Neighboring gene putative D,D-dipeptide ABC transporter membrane subunit DdpB Neighboring gene putative D,D-dipeptide ABC transporter periplasmic binding protein Neighboring gene oxygen-sensing c-di-GMP phosphodiesterase DosP Neighboring gene diguanylate cyclase DosC

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function? Lessard IA, et al. Proc Natl Acad Sci U S A, 1999 Sep 28. PMID 10500118, Free PMC Article
    2. Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. Lessard IA, et al. Chem Biol, 1998 Sep. PMID 9751644
    3. Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation. Zimmer DP, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121068, Free PMC Article
    4. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc D-Ala-D-Ala carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to starvation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    D-alanyl-D-alanine dipeptidase
    NP_416005.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1562495..1563076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416005.1 D-alanyl-D-alanine dipeptidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416005.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MKC8, A0A3L9I2V3, A0A6M9WVR4
      Conserved Domains (1) summary
      PRK10178
      Location:1 → 182
      PRK10178; D-alanyl-D-alanine dipeptidase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.