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    marB multiple antibiotic resistance protein MarB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946184, updated on 3-Dec-2024

    Summary

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    Official Symbol
    marB
    Official Full Name
    multiple antibiotic resistance protein MarB
    Primary source
    ECOCYC:EG11599
    Locus tag
    b1532
    See related
    ASAP:ABE-0005114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1525
    Summary
    marB is part of the marRAB operon, which is known to have a role in multiple antibiotic resistance. marB encodes a small putative protein of unknown function . [More information is available at EcoCyc: EG11599].
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    Genomic context

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    Sequence:
    NC_000913.3 (1619989..1620207)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor MarR Neighboring gene DNA-binding transcriptional dual regulator MarA Neighboring gene cysteine/O-acetylserine exporter EamA Neighboring gene dipeptide exporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 216-bp marB gene of the marRAB operon in Escherichia coli encodes a periplasmic protein which reduces the transcription rate of marA. Vinué L, et al. FEMS Microbiol Lett, 2013 Aug. PMID 23710538, Free PMC Article
    2. Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli. Gambino L, et al. J Bacteriol, 1993 May. PMID 8491710, Free PMC Article
    3. Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli. Ariza RR, et al. J Bacteriol, 1994 Jan. PMID 8282690, Free PMC Article
    4. Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli. Seoane AS, et al. J Bacteriol, 1995 Jun. PMID 7768850, Free PMC Article
    5. Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones. Goldman JD, et al. Antimicrob Agents Chemother, 1996 May. PMID 8723480, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MarB encodes a periplasmic protein which reduces the transcription rate of marA.
      Title: The 216-bp marB gene of the marRAB operon in Escherichia coli encodes a periplasmic protein which reduces the transcription rate of marA.
    2. role of marRAB in susceptibility to cationic antimicrobial peptides
      Title: Different effects of transcriptional regulators MarA, SoxS and Rob on susceptibility of Escherichia coli to cationic antimicrobial peptides (CAMPs): Rob-dependent CAMP induction of the marRAB operon.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multiple antibiotic resistance protein MarB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1619989..1620207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416049.1 multiple antibiotic resistance protein MarB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416049.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK10106
      Location:8 → 72
      PRK10106; multiple antibiotic resistance protein MarB
    Nucleotide Protein
    Heading Accession and Version

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