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    fadD long-chain-fatty-acid--CoA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946327, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fadD
    Official Full Name
    long-chain-fatty-acid--CoA ligase
    Primary source
    ECOCYC:EG11530
    Locus tag
    b1805
    See related
    ASAP:ABE-0006005
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1803; oldD
    Summary
    The FadD protein, encoding fatty acyl-CoA synthetase, can transport long chain fatty acids across the inner membrane in an in vitro system . [More information is available at EcoCyc: EG11530].
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    Genomic context

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    Sequence:
    NC_000913.3 (1888061..1889746, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene carnitine monooxygenase subunit YeaX Neighboring gene RNase D Neighboring gene Slp family lipoprotein YeaY Neighboring gene N(6)-L-threonylcarbamoyladenine synthase, TsaB subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase. Black PN, et al. J Biol Chem, 1992 Dec 15. PMID 1460045
    2. Partial purification and properties of acyl-CoA synthetase of Escherichia coli. Samuel D, et al. Eur J Biochem, 1970 Feb. PMID 4909455
    3. Bacterial long chain fatty acid transport: gateway to a fatty acid-responsive signaling system. Dirusso CC, et al. J Biol Chem, 2004 Nov 26. PMID 15347640
    4. Biochemical demonstration of the involvement of fatty acyl-CoA synthetase in fatty acid translocation across the plasma membrane. Schmelter T, et al. J Biol Chem, 2004 Jun 4. PMID 15067008
    5. Purification and characterization of acyl coenzyme A synthetase from Escherichia coli. Kameda K, et al. J Biol Chem, 1981 Jun 10. PMID 7016858

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRP-cAMP complex directly activates expression of fadL and fadD genes.
      Title: Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables decanoate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity, forming carbon-sulfur bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oleic acid binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase
    NP_416319.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1888061..1889746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416319.1 long-chain-fatty-acid--CoA ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416319.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7ELC5
      Conserved Domains (1) summary
      PRK08974
      Location:1 → 560
      PRK08974; long-chain-fatty-acid--CoA ligase FadD
    Nucleotide Protein
    Heading Accession and Version

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