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    uvrY DNA-binding transcriptional activator UvrY [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946424, updated on 3-Dec-2024

    Summary

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    Official Symbol
    uvrY
    Official Full Name
    DNA-binding transcriptional activator UvrY
    Primary source
    ECOCYC:EG11140
    Locus tag
    b1914
    See related
    ASAP:ABE-0006373
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1913; yecB
    Summary
    Salmonella ortholog regulates virulence gene expression. [More information is available at EcoGene: EG11140]. The protein belongs to the LuxR/UhpA family. [More information is available at EcoCyc: EG11140].
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    Genomic context

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    Sequence:
    NC_000913.3 (1994703..1995359, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene UvrABC excision nuclease subunit C Neighboring gene protein YecU Neighboring gene DUF2594 domain-containing protein YecF Neighboring gene DNA-binding transcriptional dual regulator SdiA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily. Johnston C, et al. Mol Microbiol, 1996 Nov. PMID 8951818
    2. Salmonella SirA is a global regulator of genes mediating enteropathogenesis. Ahmer BM, et al. Mol Microbiol, 1999 Feb. PMID 10048039
    3. A Novel Role of the Two-Component System Response Regulator UvrY in Enterohemorrhagic Escherichia coli O157:H7 Pathogenicity Regulation. Wu P, et al. Int J Mol Sci, 2023 Jan 24. PMID 36768620, Free PMC Article
    4. Regulation of the Escherichia coli excision repair gene uvrC. Overlap between the uvrC structural gene and the region coding for a 24 kD protein. Moolenaar GF, et al. Nucleic Acids Res, 1987 May 26. PMID 3295776, Free PMC Article
    5. pH-dependent activation of the BarA-UvrY two-component system in Escherichia coli. Mondragón V, et al. J Bacteriol, 2006 Dec. PMID 16980446, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli.
      Title: Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli.
    2. A Novel Role of the Two-Component System Response Regulator UvrY in Enterohemorrhagic Escherichia coli O157:H7 Pathogenicity Regulation.
      Title: A Novel Role of the Two-Component System Response Regulator UvrY in Enterohemorrhagic Escherichia coli O157:H7 Pathogenicity Regulation.
    3. CsrA positively affects uvrY expression, at both the transcriptional and translational levels.
      Title: Effects of the global regulator CsrA on the BarA/UvrY two-component signaling system.
    4. The role of Escherichia coli BarA-UvrY two-component system in virulence using a monkey cystitis model is reported.
      Title: The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tract.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay response regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator UvrY

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1994703..1995359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416424.1 DNA-binding transcriptional activator UvrY [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416424.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376J915
      Conserved Domains (1) summary
      PRK09483
      Location:1 → 218
      PRK09483; response regulator; Provisional
    Nucleotide Protein
    Heading Accession and Version

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