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    mtfA Mlc titration factor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946489, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mtfA
    Official Full Name
    Mlc titration factor
    Primary source
    ECOCYC:G7063
    Locus tag
    b1976
    See related
    ASAP:ABE-0006558
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1972; yeeI
    Summary
    An mtfA mutation has elevated ptsG activity; overproduction increases pstG and dgsA(mlc) expression. [More information is available at EcoGene: EG13377]. MtfA interacts with the transcriptional repressor Mlc and thus modulates the expression of genes which are regulated by Mlc . [More information is available at EcoCyc: G7063].
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    Genomic context

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    Sequence:
    NC_000913.3 (2043651..2044448)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative cytochrome b561 YodB Neighboring gene tRNA-Ser Neighboring gene tRNA-Asn Neighboring gene inverse autotransporter adhesin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of MtfA, a novel regulatory output signal protein of the glucose-phosphotransferase system in Escherichia coli K-12. Göhler AK, et al. J Bacteriol, 2012 Mar. PMID 22178967, Free PMC Article
    2. YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12. Becker AK, et al. J Bacteriol, 2006 Aug. PMID 16855233, Free PMC Article
    3. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
    4. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Based on these findings, the authors propose a model of MtfA as a glucose-regulated peptidase activated by cytoplasmic Mlc.
      Title: Characterization of MtfA, a novel regulatory output signal protein of the glucose-phosphotransferase system in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mlc titration factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2043651..2044448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416484.2 Mlc titration factor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416484.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A403D3B4
      Conserved Domains (1) summary
      PRK15410
      Location:1 → 260
      PRK15410; DgsA anti-repressor MtfA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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