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    menB 1,4-dihydroxy-2-naphthoyl-CoA synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946747, updated on 3-Dec-2024

    Summary

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    Official Symbol
    menB
    Official Full Name
    1,4-dihydroxy-2-naphthoyl-CoA synthase
    Primary source
    ECOCYC:EG11368
    Locus tag
    b2262
    See related
    ASAP:ABE-0007476
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2256
    Summary
    Naphthoate-CoA synthase catalyzes a major step in menaquinone biosynthesis, formation of the bicyclic ring system . [More information is available at EcoCyc: EG11368].
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    Genomic context

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    Sequence:
    NC_000913.3 (2375962..2376819, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene o-succinylbenzoate synthase Neighboring gene 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Neighboring gene 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase Neighboring gene isochorismate synthase MenF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member. Li HJ, et al. Biochemistry, 2011 Nov 8. PMID 21830810, Free PMC Article
    2. A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli. Jiang M, et al. J Biol Chem, 2010 Sep 24. PMID 20643650, Free PMC Article
    3. Biosynthesis of o-succinylbenzoic acid in a men- Escherichia coli mutant requires decarboxylation of L-glutamate at the C-1 position. Meganathan R, et al. Biochemistry, 1981 Sep 1. PMID 6117313
    4. Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis. Heide L, et al. J Biol Chem, 1982 Jul 10. PMID 7045104
    5. Biosynthesis of bacterial menaquinones. Menaquinone mutants of Escherichia coli. Young IG. Biochemistry, 1975 Jan 28. PMID 1091286

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 1,4-dihydroxy-2-naphthoyl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,4-dihydroxy-2-naphthoyl-CoA synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1,4-dihydroxy-2-naphthoyl-CoA synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bicarbonate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in menaquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in menaquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within menaquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1,4-dihydroxy-2-naphthoyl-CoA synthase
    NP_416765.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2375962..2376819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416765.1 1,4-dihydroxy-2-naphthoyl-CoA synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416765.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7KCU4
      Conserved Domains (1) summary
      PRK07396
      Location:10 → 285
      PRK07396; dihydroxynaphthoic acid synthetase; Validated
    Nucleotide Protein
    Heading Accession and Version

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