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    gcvR putative transcriptional regulator GcvR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946950, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gcvR
    Official Full Name
    putative transcriptional regulator GcvR
    Primary source
    ECOCYC:EG11149
    Locus tag
    b2479
    See related
    ASAP:ABE-0008168
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2475; yffD
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    Genomic context

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    Sequence:
    NC_000913.3 (2599906..2600478)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane protein assembly factor BamC Neighboring gene 4-hydroxy-tetrahydrodipicolinate synthase Neighboring gene thiol peroxidase Neighboring gene hydrogenase 4 component A Neighboring gene hydrogenase 4 component B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Promoter characterization and constitutive expression of the Escherichia coli gcvR gene. Ghrist AC, et al. J Bacteriol, 1998 Apr. PMID 9537378, Free PMC Article
    2. GcvR interacts with GcvA to inhibit activation of the Escherichia coli glycine cleavage operon. Ghrist AC, et al. Microbiology (Reading), 2001 Aug. PMID 11495998
    3. A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map. Andrews SC, et al. J Gen Microbiol, 1991 Feb. PMID 2016588
    4. Characterization of the Escherichia coli gcvR gene encoding a negative regulator of gcv expression. Ghrist AC, et al. J Bacteriol, 1995 Sep. PMID 7665475, Free PMC Article
    5. Glycine binds the transcriptional accessory protein GcvR to disrupt a GcvA/GcvR interaction and allow GcvA-mediated activation of the Escherichia coli gcvTHP operon. Heil G, et al. Microbiology (Reading), 2002 Jul. PMID 12101307

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Promoter characterization and constitutive expression of the Escherichia coli gcvR gene.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative transcriptional regulator GcvR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2599906..2600478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416974.4 putative transcriptional regulator GcvR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416974.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9GB60
      Conserved Domains (1) summary
      PRK11589
      Location:1 → 190
      gcvR; glycine cleavage system transcriptional repressor; Provisional
    Nucleotide Protein
    Heading Accession and Version

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