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    hyfR DNA-binding transcriptional activator HyfR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948886, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hyfR
    Official Full Name
    DNA-binding transcriptional activator HyfR
    Primary source
    ECOCYC:G7308
    Locus tag
    b2491
    See related
    ASAP:ABE-0008204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2487
    Summary
    HyfR , "hydrogenase four regulator," controls the expression of genes responsible for the proton-translocating formate hydrogenase system and for formate transport under anaerobiosis, low pH, and post-exponential growth conditions . [More information is available at EcoCyc: G7308].
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    Genomic context

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    Sequence:
    NC_000913.3 (2611900..2613912)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 4 component H Neighboring gene hydrogenase 4 catalytic subunit HyfI Neighboring gene putative hydrogenase 4 assembly protein Neighboring gene formate channel FocB Neighboring gene putative transporter YfgO

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Copper (II) ions affect Escherichia coli membrane vesicles' SH-groups and a disulfide-dithiol interchange between membrane proteins. Kirakosyan G, et al. Cell Biochem Biophys, 2008. PMID 18458828
    2. Dissecting the roles of Escherichia coli hydrogenases in biohydrogen production. Redwood MD, et al. FEMS Microbiol Lett, 2008 Jan. PMID 17995952
    3. Expression and regulation of a silent operon, hyf, coding for hydrogenase 4 isoenzyme in Escherichia coli. Self WT, et al. J Bacteriol, 2004 Jan. PMID 14702328, Free PMC Article
    4. A 12-cistron Escherichia coli operon (hyf) encoding a putative proton-translocating formate hydrogenlyase system. Andrews SC, et al. Microbiology (Reading), 1997 Nov. PMID 9387241
    5. Regulation of the hydrogenase-4 operon of Escherichia coli by the sigma(54)-dependent transcriptional activators FhlA and HyfR. Skibinski DA, et al. J Bacteriol, 2002 Dec. PMID 12426353, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator HyfR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2611900..2613912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416986.4 DNA-binding transcriptional activator HyfR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416986.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A831GQH7
      Conserved Domains (1) summary
      COG3604
      Location:118 → 669
      FhlA; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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