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    glrR DNA-binding transcriptional activator GlrR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947042, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glrR
    Official Full Name
    DNA-binding transcriptional activator GlrR
    Primary source
    ECOCYC:EG11285
    Locus tag
    b2554
    See related
    ASAP:ABE-0008400
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2551; qseF; yfhA
    Summary
    Characterized in an EPEC strain, QseC activates transcription of qseEGF in response to the autoinducer-3 (AI-3)/epinephrine/norepinephrine interkingdom signaling system (Reading, 2007). [More information is available at EcoGene: EG11285]. Purified YfhA can be phosphorylated in vitro by the cognate histidine kinase YfhK as well as by the non-cognate histidine kinases UhpB, RstB, and BaeS . [More information is available at EcoCyc: EG11285].
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    Genomic context

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    Sequence:
    NC_000913.3 (2687469..2688803, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene nitric oxide dioxygenase Neighboring gene nitrogen regulatory protein PII-1 Neighboring gene outer membrane lipoprotein QseG Neighboring gene histidine kinase GlrK Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cascade control of Escherichia coli glutamine synthetase. Purification and properties of PII protein and nucleotide sequence of its structural gene. Son HS, et al. J Biol Chem, 1987 Jun 25. PMID 2885322
    2. The glnB region of the Escherichia coli chromosome. Liu J, et al. J Bacteriol, 1993 Nov. PMID 8226691, Free PMC Article
    3. Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli. Göpel Y, et al. PLoS Genet, 2018 Jul. PMID 30040820, Free PMC Article
    4. Isolation and nucleotide sequence of the hmp gene that encodes a haemoglobin-like protein in Escherichia coli K-12. Vasudevan SG, et al. Mol Gen Genet, 1991 Apr. PMID 2034230
    5. Dual control by perfectly overlapping sigma 54- and sigma 70- promoters adjusts small RNA GlmY expression to different environmental signals. Reichenbach B, et al. Mol Microbiol, 2009 Dec. PMID 19843219

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reveal a three-component signaling system in E. coli K-12, in which membrane-bound QseE is stimulated through interaction with periplasmic QseG to phosphorylate cytoplasmic QseF.
      Title: Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli.
    2. QseE and QseF are involved in the transcriptional control of genes necessary for pedestal formation
      Title: The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay response regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorelay signal transduction system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator GlrR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2687469..2688803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417049.1 DNA-binding transcriptional activator GlrR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417049.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AT71, A0A7L7EIB0, A0AAN5UAA1
      Conserved Domains (1) summary
      PRK15115
      Location:1 → 444
      PRK15115; response regulator GlrR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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