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    hypE carbamoyl dehydratase HypE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947182, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hypE
    Official Full Name
    carbamoyl dehydratase HypE
    Primary source
    ECOCYC:EG10487
    Locus tag
    b2730
    See related
    ASAP:ABE-0008967
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2725; hydB
    Summary
    HypF adds the C-terminal thiocarbamate to HypE. [More information is available at EcoGene: EG10487]. HypE is one of the hydrogenase maturation proteins required for the assembly of the CN ligand of the NiFe metal center of hydrogenase 1, 2 and 3. [More information is available at EcoCyc: EG10487].
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    Genomic context

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    Sequence:
    NC_000913.3 (2853254..2854264)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 3 nickel incorporation protein HypA Neighboring gene hydrogenase isoenzymes nickel incorporation protein HypB Neighboring gene hydrogenase maturation factor HypC Neighboring gene Fe-(CN)2CO cofactor assembly scaffold protein HypD Neighboring gene DNA-binding transcriptional activator FhlA Neighboring gene protein YgbA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electron inventory of the iron-sulfur scaffold complex HypCD essential in [NiFe]-hydrogenase cofactor assembly. Stripp ST, et al. Biochem J, 2021 Sep 17. PMID 34409988, Free PMC Article
    2. Biochemical and genetic analysis of hydrogen metabolism in Escherichia coli: the hydB gene. Sankar P, et al. J Bacteriol, 1988 Dec. PMID 2848007, Free PMC Article
    3. Extracellular iron reduction is mediated in part by neutral red and hydrogenase in Escherichia coli. McKinlay JB, et al. Appl Environ Microbiol, 2004 Jun. PMID 15184145, Free PMC Article
    4. Identification of an Isothiocyanate on the HypEF Complex Suggests a Route for Efficient Cyanyl-Group Channeling during [NiFe]-Hydrogenase Cofactor Generation. Stripp ST, et al. PLoS One, 2015. PMID 26186649, Free PMC Article
    5. Pleiotropic hydrogenase mutants of Escherichia coli K12: growth in the presence of nickel can restore hydrogenase activity. Waugh R, et al. Biochimie, 1986 Jan. PMID 3015243

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein-containing complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbamoyl dehydratase HypE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2853254..2854264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417210.2 carbamoyl dehydratase HypE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417210.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M3H7
      Conserved Domains (1) summary
      TIGR02124
      Location:15 → 336
      hypE; hydrogenase expression/formation protein HypE
    Nucleotide Protein
    Heading Accession and Version

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