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    prlF antitoxin PrlF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947639, updated on 17-Dec-2024

    Summary

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    Official Symbol
    prlF
    Official Full Name
    antitoxin PrlF
    Primary source
    ECOCYC:EG10955
    Locus tag
    b3129
    See related
    ASAP:ABE-0010287
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3117; prlFA; sohA
    Summary
    PrlF is the antitoxin component in the PrlF-YhaV antitoxin-toxin complex. [More information is available at EcoCyc: EG10955].
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    Genomic context

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    Sequence:
    NC_000913.3 (3277002..3277337)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactarate/D-glucarate transporter GarP Neighboring gene GarD Neighboring gene ribosome-dependent mRNA interferase toxin YhaV Neighboring gene DNA-binding transcriptional repressor AgaR Neighboring gene putative tagatose-1,6-bisphosphate aldolase 1 chaperone

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced export of beta-galactosidase fusion proteins in prlF mutants is Lon dependent. Snyder WB, et al. J Bacteriol, 1992 Sep. PMID 1512198, Free PMC Article
    2. Identification, cloning, and characterization of the Escherichia coli sohA gene, a suppressor of the htrA (degP) null phenotype. Baird L, et al. J Bacteriol, 1990 Mar. PMID 2407727, Free PMC Article
    3. Mutation prlF1 relieves the lethality associated with export of beta-galactosidase hybrid proteins in Escherichia coli. Kiino DR, et al. J Bacteriol, 1984 Jun. PMID 6233268, Free PMC Article
    4. Increased expression of the bifunctional protein PrlF suppresses overproduction lethality associated with exported beta-galactosidase hybrid proteins in Escherichia coli. Kiino DR, et al. J Bacteriol, 1990 Jan. PMID 2152898, Free PMC Article
    5. prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. Schmidt O, et al. J Mol Biol, 2007 Sep 28. PMID 17706670, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that prlF and yhaV encode a novel toxin-antitoxin system in Escherichia coli.
      Title: prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables toxin sequestering activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables toxin sequestering activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in single-species biofilm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antitoxin PrlF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3277002..3277337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417598.1 antitoxin PrlF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417598.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2Y0SKJ1, A0A7U9LIN0
      Conserved Domains (1) summary
      PRK09974
      Location:4 → 111
      PRK09974; type II toxin-antitoxin system PrlF family antitoxin
    Nucleotide Protein
    Heading Accession and Version

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