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    mlaB intermembrane phospholipid transport system protein MlaB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947954, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mlaB
    Official Full Name
    intermembrane phospholipid transport system protein MlaB
    Primary source
    ECOCYC:G7658
    Locus tag
    b3191
    See related
    ASAP:ABE-0010487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3180; yrbB
    Summary
    The STAS domain is found in sulfate transporters and anti-sigmas and may bind NTPs. [More information is available at EcoGene: EG12797].
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    Genomic context

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    Sequence:
    NC_000913.3 (3336963..3337256, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine 1-carboxyvinyltransferase Neighboring gene acid stress protein IbaG Neighboring gene intermembrane phospholipid transport system - periplasmic binding protein Neighboring gene intermembrane phospholipid transport system, substrate binding protein MlaD Neighboring gene intermembrane phospholipid transport system, integral membrane subunit MlaE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation. Kolich LR, et al. Elife, 2020 Jun 30. PMID 32602838, Free PMC Article
    2. Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Tang X, et al. Nat Struct Mol Biol, 2021 Jan. PMID 33199922
    3. Unanticipated functional diversity among the TatA-type components of the Tat protein translocase. Eimer E, et al. Sci Rep, 2018 Jan 22. PMID 29358647, Free PMC Article
    4. Escherichia coli genes that reduce the lethal effects of stress. Han X, et al. BMC Microbiol, 2010 Feb 4. PMID 20128927, Free PMC Article
    5. Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. Thong S, et al. Elife, 2016 Aug 16. PMID 27529189, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables phospholipid transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intermembrane phospholipid transfer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of phospholipid-translocating ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intermembrane phospholipid transport system protein MlaB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3336963..3337256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417658.4 intermembrane phospholipid transport system protein MlaB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417658.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ATC2
      Conserved Domains (1) summary
      NF033618
      Location:3 → 96
      mlaB_1; lipid asymmetry maintenance protein MlaB
    Nucleotide Protein
    Heading Accession and Version

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