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    kdsC 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947717, updated on 3-Dec-2024

    Summary

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    Official Symbol
    kdsC
    Official Full Name
    3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
    Primary source
    ECOCYC:G7663
    Locus tag
    b3198
    See related
    ASAP:ABE-0010506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3187; yrbI; yrbJ
    Summary
    YrbI is renamed as KdsC (personal comm., R.W. [More information is available at EcoGene: EG12804]. 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase is specific for the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate. [More information is available at EcoCyc: G7663].
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    Genomic context

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    Sequence:
    NC_000913.3 (3342273..3342839)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YrbG Neighboring gene D-arabinose 5-phosphate isomerase KdsD Neighboring gene lipopolysaccharide transport system protein LptC Neighboring gene lipopolysaccharide transport system protein LptA Neighboring gene lipopolysaccharide transport system ATP binding protein LptB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The tail of KdsC: conformational changes control the activity of a haloacid dehalogenase superfamily phosphatase. Biswas T, et al. J Biol Chem, 2009 Oct 30. PMID 19726684, Free PMC Article
    2. From structure to function: YrbI from Haemophilus influenzae (HI1679) is a phosphatase. Parsons JF, et al. Proteins, 2002 Mar 1. PMID 11835514, Free PMC Article
    3. 3-Deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) phosphatase. Ray PH, et al. Methods Enzymol, 1982. PMID 6285136
    4. Purification and characterization of specific 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Escherichia coli B. Ray PH, et al. J Bacteriol, 1980 Apr. PMID 6246070, Free PMC Article
    5. Escherichia coli YrbI is 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase. Wu J, et al. J Biol Chem, 2003 May 16. PMID 12639950

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. structural and kinetic analysis strongly suggests that the binding of the flexible C-terminal region (tail) to the active site makes KdsC catalytically efficient by facilitating product release
      Title: The tail of KdsC: conformational changes control the activity of a haloacid dehalogenase superfamily phosphatase.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Escherichia coli YrbI is 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-deoxy-manno-octulosonate-8-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
    NP_417665.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3342273..3342839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417665.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417665.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M1V1, A0A8T5Y7Y3
      Conserved Domains (1) summary
      PRK09484
      Location:6 → 188
      PRK09484; 3-deoxy-manno-octulosonate-8-phosphatase KdsC
    Nucleotide Protein
    Heading Accession and Version

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