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    tag 3-methyl-adenine DNA glycosylase I, constitutive [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947137, updated on 17-Dec-2024

    Summary

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    Official Symbol
    tag
    Official Full Name
    3-methyl-adenine DNA glycosylase I, constitutive
    Primary source
    ECOCYC:EG10986
    Locus tag
    b3549
    See related
    ASAP:ABE-0011593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3536; tagA
    Summary
    Tag is constitutively expressed. [More information is available at EcoGene: EG10986]. Alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate (MMS) can produce potentially mutagenic lesions in DNA. [More information is available at EcoCyc: EG10986].
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    Genomic context

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    Sequence:
    NC_000913.3 (3713092..3713655)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YhjX Neighboring gene putative outer membrane protein YhjY Neighboring gene peptidyl-lysine N-acetyltransferase YiaC Neighboring gene biotin sulfoxide reductase Neighboring gene PF13488 family lipoprotein YiaD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of the tag gene from Escherichia coli. Steinum AL, et al. Nucleic Acids Res, 1986 May 12. PMID 3520491, Free PMC Article
    2. DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG). Metz AH, et al. EMBO J, 2007 May 2. PMID 17410210, Free PMC Article
    3. 3-Methyladenine-DNA glycosylase I from Escherichia coli-computer modeling and supporting experimental evidence. Plochocka D, et al. Biochem Biophys Res Commun, 2000 Feb 24. PMID 10679272
    4. Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli. Sakumi K, et al. J Biol Chem, 1986 Nov 25. PMID 3536912
    5. Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction. Rydberg B, et al. EMBO J, 1982. PMID 7188181, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA-3-methyladenine glycosylase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA-3-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA alkylation repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-methyl-adenine DNA glycosylase I, constitutive
    NP_418005.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3713092..3713655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418005.1 3-methyl-adenine DNA glycosylase I, constitutive [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418005.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAX2K3Y3
      Conserved Domains (1) summary
      PRK10353
      Location:1 → 187
      PRK10353; DNA-3-methyladenine glycosylase I
    Nucleotide Protein
    Heading Accession and Version

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