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    selA selenocysteine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948124, updated on 3-Dec-2024

    Summary

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    Official Symbol
    selA
    Official Full Name
    selenocysteine synthase
    Primary source
    ECOCYC:EG10941
    Locus tag
    b3591
    See related
    ASAP:ABE-0011731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3580; fdhA
    Summary
    Selenocysteine synthase is encoded by the selA gene . [More information is available at EcoCyc: EG10941].
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    Genomic context

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    Sequence:
    NC_000913.3 (3759858..3761249, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase B Neighboring gene L-threonine dehydrogenase Neighboring gene selenocysteyl-tRNA-specific translation elongation factor Neighboring gene glutathione transferase-like protein YibF Neighboring gene rhs element protein RhsA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dimer-dimer interaction of the bacterial selenocysteine synthase SelA promotes functional active-site formation and catalytic specificity. Itoh Y, et al. J Mol Biol, 2014 Apr 17. PMID 24456689, Free PMC Article
    2. Structure of selenocysteine synthase from Escherichia coli and location of tRNA in the seryl-tRNA(sec)-enzyme complex. Engelhardt H, et al. Mol Microbiol, 1992 Dec. PMID 1474891
    3. The progress in mechanism of selenoprotein biosynthesis. Jiang ZH, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Jul. PMID 12098758
    4. Formation of a Ternary Complex for Selenocysteine Biosynthesis in Bacteria. Silva IR, et al. J Biol Chem, 2015 Dec 4. PMID 26378233, Free PMC Article
    5. Assembly stoichiometry of bacterial selenocysteine synthase and SelC (tRNAsec). Manzine LR, et al. FEBS Lett, 2013 Apr 2. PMID 23428847

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-seryl-tRNA(Sec) selenium transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-seryl-tRNA(Sec) selenium transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-seryl-tRNA(Sec) selenium transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in selenocysteine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in selenocysteine incorporation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    selenocysteine synthase
    NP_418048.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3759858..3761249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418048.1 selenocysteine synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418048.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YIB5
      Conserved Domains (1) summary
      PRK04311
      Location:3 → 463
      PRK04311; selenocysteine synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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