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    phnH carbon-phosphorus lyase core complex subunit PhnH [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948619, updated on 17-Dec-2024

    Summary

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    Official Symbol
    phnH
    Official Full Name
    carbon-phosphorus lyase core complex subunit PhnH
    Primary source
    ECOCYC:EG10717
    Locus tag
    b4100
    See related
    ASAP:ABE-0013430
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4093
    Summary
    Phosphonate utilization is cryptic in K-12. [More information is available at EcoGene: EG10717]. PhnH appears to be a component of a carbon-phosphorous lyase enzyme. phnHis part of an operon that is phosphate starvation-inducible and required for use of phosphonate and phosphite as phosphorous sources . [More information is available at EcoCyc: EG10717].
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    Genomic context

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    Sequence:
    NC_000913.3 (4320663..4321247, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene carbon-phosphorus lyase subunit PhnK Neighboring gene carbon-phosphorus lyase core complex subunit PhnJ Neighboring gene carbon-phosphorus lyase core complex subunit PhnI Neighboring gene carbon-phosphorus lyase core complex subunit PhnG Neighboring gene putative transcriptional regulator PhnF Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of PhnH: an essential component of carbon-phosphorus lyase in Escherichia coli. Adams MA, et al. J Bacteriol, 2008 Feb. PMID 17993513, Free PMC Article
    2. Accumulation of intermediates of the carbon-phosphorus lyase pathway for phosphonate degradation in phn mutants of Escherichia coli. Hove-Jensen B, et al. J Bacteriol, 2010 Jan. PMID 19854894, Free PMC Article
    3. Five phosphonate operon gene products as components of a multi-subunit complex of the carbon-phosphorus lyase pathway. Jochimsen B, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21705661, Free PMC Article
    4. Mapping and molecular cloning of the phn (psiD) locus for phosphonate utilization in Escherichia coli. Wanner BL, et al. J Bacteriol, 1990 Mar. PMID 2155195, Free PMC Article
    5. Phosphate-independent expression of the carbon-phosphorus lyase activity of Escherichia coli. Yakovleva GM, et al. Appl Microbiol Biotechnol, 1998 May. PMID 9650256

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within organic phosphonate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic phosphonate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organic phosphonate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic phosphonate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of carbon phosphorus lyase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of carbon phosphorus lyase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbon-phosphorus lyase core complex subunit PhnH
    NP_418524.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4320663..4321247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418524.1 carbon-phosphorus lyase core complex subunit PhnH [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418524.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7L7ED51
      Conserved Domains (1) summary
      COG3625
      Location:1 → 193
      PhnH; Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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