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    cadB lysine:cadaverine antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948654, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cadB
    Official Full Name
    lysine:cadaverine antiporter
    Primary source
    ECOCYC:EG10132
    Locus tag
    b4132
    See related
    ASAP:ABE-0013530
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4126
    Summary
    Induction of the cadBA operon under acidic conditions and in the presence of lycine neutralized extracellualr environment and enabled production of CO(2); production of cadaverine and aminopropylcadaverine instead of putrescine and spermidine also resulted. cadAB operon induction also generated a proton motive force. [More information is available at EcoGene: EG10132]. CadB, a lysine:cadaverine antiporter, is part of the lysine-dependent acid resistance system 4 (AR4) which confers resistance to weak acids produced during carbohydrate fermentation under conditions of anaerobiosis and phosphate starvation. [More information is available at EcoCyc: EG10132].
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    Genomic context

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    Sequence:
    NC_000913.3 (4358697..4360031, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dipeptide/tripeptide:H(+) symporter DtpC Neighboring gene lysine decarboxylase 1 Neighboring gene DNA-binding transcriptional activator CadC Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of cadBA in an Escherichia coli lysine auxotroph transformed with a cad-gfp transcriptional fusion. Chalova VI, et al. Antonie Van Leeuwenhoek, 2009 May. PMID 19241138
    2. Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH. Meng SY, et al. J Bacteriol, 1992 Apr. PMID 1556085, Free PMC Article
    3. Identification and characterization of "pathoadaptive mutations" of the cadBA operon in several intestinal Escherichia coli. Jores J, et al. Int J Med Microbiol, 2006 Dec. PMID 17027337
    4. Internal pH crisis, lysine decarboxylase and the acid tolerance response of Salmonella typhimurium. Park YK, et al. Mol Microbiol, 1996 May. PMID 8736539
    5. The cad locus of Enterobacteriaceae: more than just lysine decarboxylation. Torres AG. Anaerobe, 2009 Feb-Apr. PMID 18572426

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables lysine:cadaverine antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-lysine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cadaverine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cadaverine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular stress response to acidic pH IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine:cadaverine antiporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4358697..4360031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418556.1 lysine:cadaverine antiporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418556.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9AEM0
      Conserved Domains (1) summary
      PRK10435
      Location:1 → 435
      cadB; cadaverine/lysine antiporter
    Nucleotide Protein
    Heading Accession and Version

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