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    aspA aspartate ammonia-lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948658, updated on 3-Dec-2024

    Summary

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    Official Symbol
    aspA
    Official Full Name
    aspartate ammonia-lyase
    Primary source
    ECOCYC:EG10095
    Locus tag
    b4139
    See related
    ASAP:ABE-0013551
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4133
    Summary
    Tetrameric enzyme. [More information is available at EcoGene: EG10095]. Aspartate-ammonia lyase (aspartase) carries out the reversible conversion of L-aspartate to fumarate and ammonia. [More information is available at EcoCyc: EG10095].
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    Genomic context

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    Sequence:
    NC_000913.3 (4366891..4368327, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene thiol-disulfide exchange protein DsbD Neighboring gene copper binding protein CutA Neighboring gene C4-dicarboxylate transporter DcuA Neighboring gene ncRNA Neighboring gene protein FxsA Neighboring gene L-methionine/branched chain amino acid exporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific inhibition of aspartase by S-2,3-dicarboxyaziridine. Higashi Y, et al. Biochem Int, 1988 Mar. PMID 3289541
    2. Biospecific inactivation of aspartase by L-aspartic-beta-semialdehyde. Yumoto N, et al. Biochem Biophys Res Commun, 1982 Feb 11. PMID 7041905
    3. Studies on aspartase. VI. Trypsin-mediated activation releasing carboxy-terminal peptides. Yumoto N, et al. Biochim Biophys Acta, 1980 Dec 4. PMID 7011387
    4. Studies on aspartase VIII. Protease-mediated activation: comparative survey of protease specificity for activation and peptide cleavage. Yumoto N, et al. Physiol Chem Phys, 1982. PMID 6764538
    5. Chemical modification of essential histidine residues in aspartase with diethylpyrocarbonate. Ida N, et al. J Biochem, 1984 Nov. PMID 6396297

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Cloning and nucleotide sequence of the aspartase gene of Escherichia coli W.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aspartate ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartate ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aspartate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in aspartate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aspartate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aspartate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    aspartate ammonia-lyase
    NP_418562.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4366891..4368327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418562.4 aspartate ammonia-lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418562.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GD51
      Conserved Domains (1) summary
      PRK12273
      Location:1 → 473
      aspA; aspartate ammonia-lyase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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