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    proC pyrroline-5-carboxylate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945034, updated on 3-Dec-2024

    Summary

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    Official Symbol
    proC
    Official Full Name
    pyrroline-5-carboxylate reductase
    Primary source
    ECOCYC:EG10769
    Locus tag
    b0386
    See related
    ASAP:ABE-0001338
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0381; pro(3); Pro2; pro3
    Summary
    Pyrroline-5-carboxylate-reductase (ProC) catalyzes the last step in proline biosynthesis. [More information is available at EcoCyc: EG10769].
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    Genomic context

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    Sequence:
    NC_000913.3 (404835..405644, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphate starvation-inducible protein PsiF Neighboring gene diguanylate cyclase DgcC Neighboring gene DUF188 domain-containing protein YaiI Neighboring gene shikimate kinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Partial purification and some properties of delta1-pyrroline-5-carboxylate reductase from Escherichia coli. Rossi JJ, et al. J Bacteriol, 1977 Jan. PMID 12133, Free PMC Article
    2. Oxidation of L-thiazolidine-4-carboxylate by delta1-pyrroline-5-carboxylate reductase in Escherichia coli. Deutch CE, et al. Curr Microbiol, 2001 Jun. PMID 11381339
    3. Isolation of haemin-requiring mutants of Escherichia coli K12. McConville ML, et al. J Gen Microbiol, 1979 Jul. PMID 387909
    4. Recombinant plasmids with genes for the biosynthesis of alkaline phosphatase of Escherichia coli. Boidol W, et al. Mol Gen Genet, 1982. PMID 6285149
    5. The gene-enzyme relationships of proline biosynthesis in Escherichia coli. Hayzer DJ, et al. J Gen Microbiol, 1980 Jun. PMID 6255065

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Analysis of the Escherichia coli proBA locus by DNA and protein sequencing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyrroline-5-carboxylate reductase
    NP_414920.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      404835..405644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414920.1 pyrroline-5-carboxylate reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414920.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7CMM4
      Conserved Domains (1) summary
      PRK11880
      Location:1 → 269
      PRK11880; pyrroline-5-carboxylate reductase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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