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    aroL shikimate kinase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945031, updated on 3-Dec-2024

    Summary

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    Official Symbol
    aroL
    Official Full Name
    shikimate kinase 2
    Primary source
    ECOCYC:EG10082
    Locus tag
    b0388
    See related
    ASAP:ABE-0001353
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0383
    Summary
    Expression of the structural gene of one of the coli shikimate kinase isoenzyme, the aroL gene product is regulated by the tyrR gene product protein with tyrosine or tryptophan as co-repressor. [More information is available at EcoCyc: EG10082].
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    Genomic context

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    Sequence:
    NC_000913.3 (406405..406929)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase Neighboring gene DUF188 domain-containing protein YaiI Neighboring gene protein YaiA Neighboring gene protein AroM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA looping. Schleif R. Science, 1988 Apr 8. PMID 3353710
    2. A reassessment of the relationship between aroK- and aroL-encoded shikimate kinase enzymes of Escherichia coli. Whipp MJ, et al. J Bacteriol, 1995 Mar. PMID 7883721, Free PMC Article
    3. Purification and properties of shikimate kinase II from Escherichia coli K-12. DeFeyter RC, et al. J Bacteriol, 1986 Jan. PMID 3001029, Free PMC Article
    4. Aromatic amino acid biosynthesis: regulation of shikimate kinase in Escherichia coli K-12. Ely B, et al. J Bacteriol, 1979 Jun. PMID 222728, Free PMC Article
    5. Naturally occurring adenines within mRNA coding sequences affect ribosome binding and expression in Escherichia coli. Brock JE, et al. J Bacteriol, 2007 Jan. PMID 17085569, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The cloning and expression of the aroL gene from Escherichia coli K12. Purification and complete amino acid sequence of shikimate kinase II, the aroL-gene product.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables shikimate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables shikimate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables shikimate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within aromatic amino acid family biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    shikimate kinase 2
    NP_414922.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      406405..406929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414922.1 shikimate kinase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414922.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9T1E0
      Conserved Domains (1) summary
      PRK03731
      Location:1 → 170
      aroL; shikimate kinase AroL
    Nucleotide Protein
    Heading Accession and Version

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