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    cusR DNA-binding transcriptional activator CusR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945003, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cusR
    Official Full Name
    DNA-binding transcriptional activator CusR
    Primary source
    ECOCYC:G6319
    Locus tag
    b0571
    See related
    ASAP:ABE-0001948
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0563; ylcA
    Summary
    CusR, "Cu-sensing regulator", regulates genes related to the copper and silver efflux systems under anaerobic growth and under extreme copper stress in aerobic growth . [More information is available at EcoCyc: G6319].
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    Genomic context

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    Sequence:
    NC_000913.3 (594760..595443, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative exopolysaccharide secretion system auxiliary component Neighboring gene exopolysaccharide secretion system outer membrane protein NfrA Neighboring gene cyclic di-3',5'-guanylate-activated glycosyltransferase Neighboring gene sensor histidine kinase CusS Neighboring gene copper/silver export system outer membrane channel Neighboring gene copper/silver export system periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12. Munson GP, et al. J Bacteriol, 2000 Oct. PMID 11004187, Free PMC Article
    2. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. Silver S. FEMS Microbiol Rev, 2003 Jun. PMID 12829274
    3. The product of the ybdE gene of the Escherichia coli chromosome is involved in detoxification of silver ions. Franke S, et al. Microbiology (Reading), 2001 Apr. PMID 11283292
    4. Escherichia coli mechanisms of copper homeostasis in a changing environment. Rensing C, et al. FEMS Microbiol Rev, 2003 Jun. PMID 12829268
    5. System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids. Gao R, et al. Mol Microbiol, 2008 Sep. PMID 18631241, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to copper ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator CusR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      594760..595443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415103.1 DNA-binding transcriptional activator CusR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415103.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A478L557
      Conserved Domains (1) summary
      PRK09836
      Location:1 → 227
      PRK09836; DNA-binding transcriptional activator CusR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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