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    rlpA rare lipoprotein RlpA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945241, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rlpA
    Official Full Name
    rare lipoprotein RlpA
    Primary source
    ECOCYC:EG10854
    Locus tag
    b0633
    See related
    ASAP:ABE-0002171
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0626
    Summary
    First 17 aa are a type II signal peptide. [More information is available at EcoGene: EG10854]. RlpA is one of two (along with RlpB) so-called rare lipoproteins in Escherichia coli. [More information is available at EcoCyc: EG10854].
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    Genomic context

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    Sequence:
    NC_000913.3 (664102..665190, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF493 domain-containing protein YbeD Neighboring gene D-alanyl-D-alanine carboxypeptidase DacA Neighboring gene peptidoglycan glycosyltransferase MrdB Neighboring gene peptidoglycan DD-transpeptidase MrdA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli. Berezuk AM, et al. Sci Rep, 2018 Aug 28. PMID 30154462, Free PMC Article
    2. The temperature sensitive mutant 72c. II. Accumulation at high temperature of ppGpp and pppGpp in the presence of protein synthesis. Takata R, et al. Mol Gen Genet, 1978 Apr 25. PMID 353496
    3. Self-enhanced accumulation of FtsN at Division Sites and Roles for Other Proteins with a SPOR domain (DamX, DedD, and RlpA) in Escherichia coli cell constriction. Gerding MA, et al. J Bacteriol, 2009 Dec. PMID 19684127, Free PMC Article
    4. Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA. Arends SJ, et al. J Bacteriol, 2010 Jan. PMID 19880599, Free PMC Article
    5. Comparative analysis of envelope proteomes in Escherichia coli B and K-12 strains. Han MJ, et al. J Microbiol Biotechnol, 2012 Apr. PMID 22534293

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of rlpA from an FtsK temperature-sensitive E. coli strain partially restored cell growth and largely suppressed cellular filamentation compared to the wild-type strain. This suggests that interaction with RlpA may be critical in suppressing septation until proper assembly of the divisome.
      Title: Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
    2. Data show that RlpA proteins localize to the septal ring in E. coli.
      Title: Discovery and characterization of three new Escherichia coli septal ring proteins that contain a SPOR domain: DamX, DedD, and RlpA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic endotransglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rare lipoprotein RlpA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      664102..665190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415166.1 rare lipoprotein RlpA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415166.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9Q9E4
      Conserved Domains (1) summary
      PRK10672
      Location:1 → 362
      PRK10672; endolytic peptidoglycan transglycosylase RlpA
    Nucleotide Protein
    Heading Accession and Version

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