ptsG glucose-specific PTS enzyme IIBC component [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: ptsG
Official Full Name: glucose-specific PTS enzyme IIBC component
Primary source: ECOCYC:EG10787
Locus tag: b1101
See related: ASAP:ABE-0003722
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: car; cat; catB2; CR; ECK1087; glcA; gptA; tgl; umg; umgC
Summary: [More information is available at EcoCyc: EG10787].
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Genomic context

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Sequence:: NC_000913.3 (1157869..1159302)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SgrT acts to specifically inhibit the transport activity of the major glucose permease PtsG.
Title: The Small Protein SgrT Controls Transport Activity of the Glucose-Specific Phosphotransferase System.
Phage HK97 genome injection requires the activities of the inner membrane glucose transporter protein, PtsG, and the periplasmic chaperone, FkpA and requirements for PtsG and FkpA are determined by the sequence of the phage tape measure protein.
Title: The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E. coli phage HK97.
This work presents the structure of a glucose PTS transporter IICB at the highest resolution achieved so far and sets the basis for future structural studies.
Title: Structure and function of the glucose PTS transporter from Escherichia coli.
crystallization of the tryptic EIIC(Glc) domain is described. A complete data set was collected to 4.5 A resolution at 100 K.
Title: Expression, purification, crystallization and preliminary X-ray analysis of the EIICGlc domain of the Escherichia coli glucose transporter.
SgrS 168-181 is a minimal base-pairing region for translational inhibition of ptsG mRNA.
Title: A minimal base-pairing region of a bacterial small RNA SgrS required for translational repression of ptsG mRNA.
ptsG activates glucose transport under oxidative stress conditions, and is regulated by the SoxRS system.
Title: Activation of glucose transport under oxidative stress in Escherichia coli.
Results show that regulation of ptsG by Mlc involves some cooperative binding of Mlc to the two Mlc operators upstream of ptsG.
Title: Switching control of expression of ptsG from the Mlc regulon to the NagC regulon.
N-terminus verified by Edman degradation on complete protein
Title: Glucose-permease of the bacterial phosphotransferase system. Gene cloning, overproduction, and amino acid sequence of enzyme IIGlc.
Data suggest that enolase within the degradosome plays a crucial role in the regulation of glucose transporter ptsG mRNA stability in response to a metabolic stress.
Title: Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-phosphocysteine-glucose phosphotransferase system transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-phosphocysteine-glucose phosphotransferase system transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-phosphocysteine-glucose phosphotransferase system transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in D-glucose import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in D-glucose import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in D-glucose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in D-glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of transmembrane transporter complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: glucose-specific PTS enzyme IIBC component

NP_415619.1

EC 2.7.1.199

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

1157869..1159302

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_415619.1 glucose-specific PTS enzyme IIBC component [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_415619.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A2W6P9T0

Conserved Domains (1) summary

PRK11089
Location:1 → 477

PRK11089; PTS system glucose-specific transporter subunits IIBC; Provisional