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    dmlA D-malate/3-isopropylmalate dehydrogenase (decarboxylating) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946319, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dmlA
    Official Full Name
    D-malate/3-isopropylmalate dehydrogenase (decarboxylating)
    Primary source
    ECOCYC:G6986
    Locus tag
    b1800
    See related
    ASAP:ABE-0005991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1798; ttuC; yeaU
    Summary
    AFMB Structural Genomics target Number 39 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13507]. YeaU is a D-malate dehydrogenase that is essential for growth on D-malate as the sole carbon source . [More information is available at EcoCyc: G6986].
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    Genomic context

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    Sequence:
    NC_000913.3 (1881912..1882997)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene leucine exporter Neighboring gene DNA-binding transcriptional regulator DmlR Neighboring gene putative transporter YeaV Neighboring gene carnitine monooxygenase subunit YeaW

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD. Karsten WE, et al. Biochemistry, 2002 Oct 8. PMID 12356321
    2. Escherichia coli D-malate dehydrogenase, a generalist enzyme active in the leucine biosynthesis pathway. Vorobieva AA, et al. J Biol Chem, 2014 Oct 17. PMID 25160617, Free PMC Article
    3. Regulation of aerobic and anaerobic D-malate metabolism of Escherichia coli by the LysR-type regulator DmlR (YeaT). Lukas H, et al. J Bacteriol, 2010 May. PMID 20233924, Free PMC Article
    4. Time-dependent translational response of E. coli to excess Zn(II). Easton JA, et al. J Biomol Tech, 2006 Dec. PMID 17122063, Free PMC Article
    5. Systems approach to refining genome annotation. Reed JL, et al. Proc Natl Acad Sci U S A, 2006 Nov 14. PMID 17088549, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-isopropylmalate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-malate dehydrogenase (decarboxylating) (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-malate dehydrogenase (decarboxylating) (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables tartrate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tartrate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in malate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within malate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-malate/3-isopropylmalate dehydrogenase (decarboxylating)
    NP_416314.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1881912..1882997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416314.1 D-malate/3-isopropylmalate dehydrogenase (decarboxylating) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416314.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7T8KVW9, A0AAN1S5I5
      Conserved Domains (1) summary
      cl00445
      Location:2 → 359
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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