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    motA motility protein A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947564, updated on 3-Dec-2024

    Summary

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    Official Symbol
    motA
    Official Full Name
    motility protein A
    Primary source
    ECOCYC:EG10601
    Locus tag
    b1890
    See related
    ASAP:ABE-0006299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1891; flaJ
    Summary
    Flagellar regulon. [More information is available at EcoGene: EG10601]. MotA and MotB comprise the stator element of the flagellar motor complex. [More information is available at EcoCyc: EG10601].
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    Genomic context

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    Sequence:
    NC_000913.3 (1976252..1977139, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein CheW Neighboring gene chemotaxis protein CheA Neighboring gene motility protein B Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator FlhC Neighboring gene DNA-binding transcriptional dual regulator FlhD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MotA protein of E. coli is a proton-conducting component of the flagellar motor. Blair DF, et al. Cell, 1990 Feb 9. PMID 2154333
    2. Overproduction of the MotA protein of Escherichia coli and estimation of its wild-type level. Wilson ML, et al. J Bacteriol, 1988 Feb. PMID 2828314, Free PMC Article
    3. Restoration of torque in defective flagellar motors. Blair DF, et al. Science, 1988 Dec 23. PMID 2849208
    4. Gene sequence and predicted amino acid sequence of the motA protein, a membrane-associated protein required for flagellar rotation in Escherichia coli. Dean GE, et al. J Bacteriol, 1984 Sep. PMID 6090403, Free PMC Article
    5. Gate-controlled proton diffusion and protonation-induced ratchet motion in the stator of the bacterial flagellar motor. Nishihara Y, et al. Proc Natl Acad Sci U S A, 2015 Jun 23. PMID 26056313, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
      Title: Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.
    2. Charge-altering mutations affecting the conserved C-terminal cluster of negatively charged residues impair motility but do not diminish Mot protein levels.
      Title: Clusters of charged residues at the C terminus of MotA and N terminus of MotB are important for function of the Escherichia coli flagellar motor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables proton channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in archaeal or bacterial-type flagellum-dependent cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bacterial-type flagellum-dependent cell motility NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in bacterial-type flagellum-dependent swarming motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bacterial-type flagellum-dependent swarming motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within proton transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bacterial-type flagellum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of bacterial-type flagellum stator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    motility protein A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1976252..1977139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416404.1 motility protein A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416404.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T3UD58
      Conserved Domains (1) summary
      PRK09110
      Location:1 → 283
      PRK09110; flagellar motor stator protein MotA
    Nucleotide Protein
    Heading Accession and Version

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