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    ccmD cytochrome c maturation protein D [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946709, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ccmD
    Official Full Name
    cytochrome c maturation protein D
    Primary source
    ECOCYC:EG12169
    Locus tag
    b2198
    See related
    ASAP:ABE-0007273
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2190; yojM
    Summary
    CcmD stabilizes CcmE in the membrane. [More information is available at EcoGene: EG12169]. CcmD is an integral membrane protein that stabilizes the interaction between CcmC and CcmE for transfer of heme between the two proteins . [More information is available at EcoCyc: EG12169].
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    Genomic context

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    Sequence:
    NC_000913.3 (2295377..2295586, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene holocytochrome c synthase CcmH component Neighboring gene thiol:disulfide oxidoreductase CcmG Neighboring gene holocytochrome c synthase CcmF component Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein B Neighboring gene cytochrome c maturation protein A Neighboring gene periplasmic nitrate reductase cytochrome c protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing heme delivery processes in cytochrome c biogenesis System I. Mavridou DA, et al. Biochemistry, 2013 Oct 15. PMID 24044352, Free PMC Article
    2. CcmD is involved in complex formation between CcmC and the heme chaperone CcmE during cytochrome c maturation. Ahuja U, et al. J Biol Chem, 2005 Jan 7. PMID 15513913
    3. Recombinant cytochromes c biogenesis systems I and II and analysis of haem delivery pathways in Escherichia coli. Feissner RE, et al. Mol Microbiol, 2006 May. PMID 16629661
    4. Extracytoplasmic prosthetic group ligation to apoproteins: maturation of c-type cytochromes. Turkarslan S, et al. Mol Microbiol, 2006 May. PMID 16629658
    5. Haem-polypeptide interactions during cytochrome c maturation. Thöny-Meyer L. Biochim Biophys Acta, 2000 Aug 15. PMID 11004446

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a function for CcmD in protein-protein interaction or membrane protein assembly required for the heme delivery process
      Title: CcmD is involved in complex formation between CcmC and the heme chaperone CcmE during cytochrome c maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytochrome c biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytochrome c biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cytochrome c biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytochrome complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytochrome complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c maturation protein D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2295377..2295586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416702.1 cytochrome c maturation protein D [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416702.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9A6Z5
      Conserved Domains (1) summary
      COG3114
      Location:3 → 69
      CcmD; Heme exporter protein D [Intracellular trafficking, secretion, and vesicular transport]
    Nucleotide Protein
    Heading Accession and Version

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