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    fabB 3-oxoacyl-[acyl carrier protein] synthase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946799, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fabB
    Official Full Name
    3-oxoacyl-[acyl carrier protein] synthase 1
    Primary source
    ECOCYC:EG10274
    Locus tag
    b2323
    See related
    ASAP:ABE-0007675
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2317; fabC
    Summary
    There are three -ketoacyl-ACP synthases (KAS) in Escherichia coli: |FRAME: [More information is available at EcoCyc: EG10274].
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    Genomic context

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    Sequence:
    NC_000913.3 (2440385..2441605, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene erythronate-4-phosphate dehydrogenase Neighboring gene putative flagella assembly protein Neighboring gene putative transporter YfcJ Neighboring gene fused tRNA 5-aminomethyl-2-thiouridylate methyltransferase and tRNA 5-aminomethyl-2-thiouridylate synthase Neighboring gene PF08891 family protein YfcL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery. Olsen JG, et al. Structure, 2001 Mar 7. PMID 11286890
    2. Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12. Tsay JT, et al. J Bacteriol, 1992 Jan. PMID 1729241, Free PMC Article
    3. beta-Ketoacyl-ACP synthase I of Escherichia coli: nucleotide sequence of the fabB gene and identification of the cerulenin binding residue. Kauppinen S, et al. Carlsberg Res Commun, 1988. PMID 3076376
    4. Role of Escherichia coli beta-ketoacyl-ACP synthase I in unsaturated fatty acid synthesis. Siggaard-Andersen M. Carlsberg Res Commun, 1988. PMID 3076377
    5. Acyl carrier protein. 13. Beta-ketoacyl acyl carrier protein synthetase from Escherichia coli. Greenspan MD, et al. J Biol Chem, 1969 Dec 10. PMID 4901371

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data taken together support a gating mechanism that regulates acyl-ACP binding and substrate delivery to the beta-ketoacyl-acyl carrier protein (ACP) synthases (FabF and FabB) active site.
      Title: Gating mechanism of elongating β-ketoacyl-ACP synthases.
    2. The authors isolated Escherichia coli mutants that had decreased frequencies of colony formation but could grow in liquid medium from a temperature-sensitive mutant collection. Mutations were identified in fabB, which is essential for the synthesis of long unsaturated fatty acids.
      Title: Isolation of colonization-defective Escherichia coli mutants reveals critical requirement for fatty acids in bacterial colony formation.
    3. the key reaction in UFA synthesis catalyzed by FabB is elongation of the cis-3-decenoyl-ACP produced by FabA.
      Title: Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB.
    4. N-terminus verified by Edman degradation on complete protein
      Title: beta-Ketoacyl-ACP synthase I of Escherichia coli: nucleotide sequence of the fabB gene and identification of the cerulenin binding residue.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl carrier protein] synthase 1
    NP_416826.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2440385..2441605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416826.1 3-oxoacyl-[acyl carrier protein] synthase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416826.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AH73, A0A6C9QG34, A0A7A7F5U5
      Conserved Domains (1) summary
      PRK07967
      Location:1 → 405
      PRK07967; beta-ketoacyl-ACP synthase I
    Nucleotide Protein
    Heading Accession and Version

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