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    narQ sensor histidine kinase NarQ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946948, updated on 17-Dec-2024

    Summary

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    Official Symbol
    narQ
    Official Full Name
    sensor histidine kinase NarQ
    Primary source
    ECOCYC:EG11460
    Locus tag
    b2469
    See related
    ASAP:ABE-0008132
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2464
    Summary
    NarQ belongs to the two component system NarQ/NarP, is a sensor-histidine kinase and is known to be a transmembrane protein composed of three domains: external sensory domain (amino-terminal), cytoplasmic transmitter domain (carboxyl-terminal) and transmembrane hydrophobic central domain (unknown funtion). [More information is available at EcoCyc: EG11460].
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    Genomic context

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    Sequence:
    NC_000913.3 (2585731..2587431)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene GDP-mannose hydrolase Neighboring gene putative oxidoreductase AegA Neighboring gene multidrug efflux pump RND permease AcrD Neighboring gene uncharacterized protein YpfM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of transmembrane signaling by sensor histidine kinases. Gushchin I, et al. Science, 2017 Jun 9. PMID 28522691
    2. Physical map location of the narQ gene of Escherichia coli. Chiang RC, et al. J Bacteriol, 1992 Dec. PMID 1447165, Free PMC Article
    3. Response to culture aeration mediated by the nitrate and nitrite sensor NarQ of Escherichia coli K-12. Stewart V, et al. Mol Microbiol, 2003 Nov. PMID 14622424
    4. Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts. Gushchin I, et al. Int J Mol Sci, 2020 Apr 28. PMID 32354084, Free PMC Article
    5. Autophosphorylation and dephosphorylation by soluble forms of the nitrate-responsive sensors NarX and NarQ from Escherichia coli K-12. Noriega CE, et al. J Bacteriol, 2008 Jun. PMID 18375557, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts.
      Title: Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts.
    2. Study presents crystal structures of the periplasmic sensor domain, the transmembrane domain, and the cytoplasmic HAMP domain of the Escherichia coli nitrate/nitrite sensor histidine kinase NarQ in the ligand-bound and mutated ligand-free states.
      Title: Mechanism of transmembrane signaling by sensor histidine kinases.
    3. Results from bacterial adenylate cyclase two-hybrid analysis revealed robust interactions for the NarX-NarL, NarQ-NarL and NarQ-NarP pairs but a much weaker interaction for the NarX-NarP pair.
      Title: Sensor-response regulator interactions in a cross-regulated signal transduction network.
    4. study showed that only a small proportion of NarX and NarQ remain phosphorylated in the absence of nitrate, resulting in efficient response regulator dephosphorylation by the remaining unphosphorylated sensors
      Title: Autophosphorylation and dephosphorylation by soluble forms of the nitrate-responsive sensors NarX and NarQ from Escherichia coli K-12.
    5. analysis of FNR regulon and its interactions with nitrate, nitrite, NarXL, and NarQP
      Title: A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, NarXL, and NarQP as Escherichia coli K12 adapts from aerobic to anaerobic growth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to nitrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to nitrite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sensor histidine kinase NarQ
    NP_416964.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2585731..2587431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416964.1 sensor histidine kinase NarQ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416964.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376D4L0, A0A8T3UGU9
      Conserved Domains (1) summary
      PRK10935
      Location:1 → 563
      PRK10935; nitrate/nitrite two-component system sensor histidine kinase NarQ
    Nucleotide Protein
    Heading Accession and Version

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