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    purC phosphoribosylaminoimidazole-succinocarboxamide synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946957, updated on 17-Dec-2024

    Summary

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    Official Symbol
    purC
    Official Full Name
    phosphoribosylaminoimidazole-succinocarboxamide synthase
    Primary source
    ECOCYC:EG10791
    Locus tag
    b2476
    See related
    ASAP:ABE-0008156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ade; ade(g); ECK2472
    Summary
    SAICAR synthase converts 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) to 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide (SAICAR). [More information is available at EcoGene: EG10791]. Overproduction and purification of PurC . [More information is available at EcoCyc: EG10791].
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    Genomic context

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    Sequence:
    NC_000913.3 (2596905..2597618, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA(Met) cytidine acetyltransferase Neighboring gene uncharacterized protein YpfJ Neighboring gene outer membrane protein assembly factor BamC Neighboring gene 4-hydroxy-tetrahydrodipicolinate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase. Nelson SW, et al. Biochemistry, 2005 Jan 18. PMID 15641804
    2. Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase. Ginder ND, et al. J Biol Chem, 2006 Jul 28. PMID 16687397
    3. Identification of the purC gene product of Escherichia coli. Parker J. J Bacteriol, 1984 Mar. PMID 6365889, Free PMC Article
    4. Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. Meyer E, et al. Biochemistry, 1992 Jun 2. PMID 1534690
    5. DNA sequence of the purC gene encoding 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide synthetase and organization of the dapA-purC region of Escherichia coli K-12. Tiedeman AA, et al. J Bacteriol, 1990 Oct. PMID 2120198, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    2. analysis of nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase
      Title: Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase.
    3. In this study, a rapid equilibrium random ter-ter kinetic mechanism is established for SAICAR synthetase by initial velocity kinetics and patterns of linear inhibition by inosine monophosphate, adenosine 5'-(beta,gamma-imido)triphosphate, and maleate.
      Title: Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cobalamin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    phosphoribosylaminoimidazole-succinocarboxamide synthase
    NP_416971.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2596905..2597618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416971.1 phosphoribosylaminoimidazole-succinocarboxamide synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416971.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2Z1E0, A0A192C9L9, A0A1X3I3R2, A0A1X3J2I1, A0A1X3JEX7, A0AA36KZF7, A0AAJ3NYK5, Q1R8Q1
      Conserved Domains (1) summary
      PRK09362
      Location:1 → 237
      PRK09362; phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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