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    iscX accessory iron-sulfur cluster assembly protein IscX [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945196, updated on 3-Dec-2024

    Summary

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    Official Symbol
    iscX
    Official Full Name
    accessory iron-sulfur cluster assembly protein IscX
    Primary source
    ECOCYC:EG12311
    Locus tag
    b2524
    See related
    ASAP:ABE-0008309
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2521; yfhJ
    Summary
    IscX physically interacts with IscS . [More information is available at EcoCyc: EG12311].
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    Genomic context

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    Sequence:
    NC_000913.3 (2656536..2656736, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein SseB Neighboring gene aminopeptidase B Neighboring gene reduced ferredoxin Neighboring gene iron-sulfur cluster biosynthesis chaperone HscA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of IscX in iron-sulfur cluster biogenesis in Escherichia coli. Kim JH, et al. J Am Chem Soc, 2014 Jun 4. PMID 24810328, Free PMC Article
    2. The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli. Roche B, et al. Mol Microbiol, 2015 Feb. PMID 25430730
    3. Hsc66, an Hsp70 homolog in Escherichia coli, is induced by cold shock but not by heat shock. Lelivelt MJ, et al. J Bacteriol, 1995 Sep. PMID 7665466, Free PMC Article
    4. A gene encoding a DnaK/hsp70 homolog in Escherichia coli. Seaton BL, et al. Proc Natl Acad Sci U S A, 1994 Mar 15. PMID 8134349, Free PMC Article
    5. Cloning, sequencing, and overexpression of a [2Fe-2S] ferredoxin gene from Escherichia coli. Ta DT, et al. J Biol Chem, 1992 Jun 5. PMID 1317854

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a genetic interaction was discovered between cyaY and iscX; validates IscX as a new bona fide Fe-S cluster biogenesis factor
      Title: The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli.
    2. Crystal structure of Escherichia coli YfhJ protein
      Title: Crystal structure of Escherichia coli YfhJ protein, a member of the ISC machinery involved in assembly of iron-sulfur clusters.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    accessory iron-sulfur cluster assembly protein IscX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2656536..2656736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417019.1 accessory iron-sulfur cluster assembly protein IscX [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417019.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376VE87
      Conserved Domains (1) summary
      PRK10721
      Location:1 → 66
      PRK10721; hypothetical protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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