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    hypA hydrogenase 3 nickel incorporation protein HypA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947195, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hypA
    Official Full Name
    hydrogenase 3 nickel incorporation protein HypA
    Primary source
    ECOCYC:EG10483
    Locus tag
    b2726
    See related
    ASAP:ABE-0008958
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2721
    Summary
    hypA mutants have increased Hydrogenase 2 activity but similar amounts of HypA protein. hypA defect suppressed by expression of hypB-E under foreign promoter, indicating a regulatory or partially redundant function. [More information is available at EcoGene: EG10483]. HypA and its homolog, HybF, are involved in the maturation of hydrogenase isozymes. [More information is available at EcoCyc: EG10483].
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    Genomic context

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    Sequence:
    NC_000913.3 (2850647..2850997)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene formate hydrogenlyase subunit HycC Neighboring gene formate hydrogenlyase subunit HycB Neighboring gene regulator of the transcriptional regulator FhlA Neighboring gene hydrogenase isoenzymes nickel incorporation protein HypB Neighboring gene hydrogenase maturation factor HypC Neighboring gene Fe-(CN)2CO cofactor assembly scaffold protein HypD Neighboring gene carbamoyl dehydratase HypE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of Selective Nickel Transfer from HypB to HypA, Escherichia coli [NiFe]-Hydrogenase Accessory Proteins. Lacasse MJ, et al. Biochemistry, 2016 Dec 13. PMID 27951644
    2. Characterization of divergent NtrA-dependent promoters in the anaerobically expressed gene cluster coding for hydrogenase 3 components of Escherichia coli. Lutz S, et al. Mol Microbiol, 1990 Jan. PMID 2181234
    3. FNR-mediated regulation of hyp expression in Escherichia coli. Messenger SL, et al. FEMS Microbiol Lett, 2003 Nov 7. PMID 14612240
    4. Escherichia coli HypA is a zinc metalloprotein with a weak affinity for nickel. Atanassova A, et al. J Bacteriol, 2005 Jul. PMID 15995183, Free PMC Article
    5. Complex formation between the Escherichia coli [NiFe]-hydrogenase nickel maturation factors. Khorasani-Motlagh M, et al. Biometals, 2019 Jun. PMID 30758762

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At different stages of the hydrogenase maturation process, HypA was observed at or near the cell membrane, as was HycE, suggesting membrane localization of the nickel insertion event.
      Title: Protein interactions and localization of the Escherichia coli accessory protein HypA during nickel insertion to [NiFe] hydrogenase.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallochaperone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nickel cation binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nickel cation binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by nickel ion transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GTPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydrogenase 3 nickel incorporation protein HypA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2850647..2850997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417206.1 hydrogenase 3 nickel incorporation protein HypA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417206.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3ELG5, A0AAJ3NW56, B1LQ46
      Conserved Domains (1) summary
      PRK03681
      Location:1 → 114
      hypA; hydrogenase/urease nickel incorporation protein HypA
    Nucleotide Protein
    Heading Accession and Version

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