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    eno enolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945032, updated on 17-Dec-2024

    Summary

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    Official Symbol
    eno
    Official Full Name
    enolase
    Primary source
    ECOCYC:EG10258
    Locus tag
    b2779
    See related
    ASAP:ABE-0009110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2773
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10258]. Enolase catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate. [More information is available at EcoCyc: EG10258].
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    Genomic context

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    Sequence:
    NC_000913.3 (2906643..2907941, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell envelope stress response protein YqcG Neighboring gene TPM domain-containing protein YgcG Neighboring gene CTP synthetase Neighboring gene nucleoside triphosphate pyrophosphohydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular recognition between Escherichia coli enolase and ribonuclease E. Nurmohamed S, et al. Acta Crystallogr D Biol Crystallogr, 2010 Sep. PMID 20823555, Free PMC Article
    2. Properties of Escherichia coli mutants deficient in enzymes of glycolysis. Irani MH, et al. J Bacteriol, 1977 Nov. PMID 410789, Free PMC Article
    3. The purification and characterization of Escherichia coli enolase. Spring TG, et al. J Biol Chem, 1971 Nov 25. PMID 4942326
    4. Functional and structural changes due to a serine to alanine mutation in the active-site flap of enolase. Poyner RR, et al. Arch Biochem Biophys, 2002 May 15. PMID 12054465
    5. Crystal structure of the Escherichia coli RNA degradosome component enolase. Kühnel K, et al. J Mol Biol, 2001 Oct 26. PMID 11676541

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystal structure of enolase bound to its cognate site from RNase E (residues 823-850) at 1.9 A resolution is presented
      Title: Molecular recognition between Escherichia coli enolase and ribonuclease E.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    3. Data suggest that enolase within the degradosome plays a crucial role in the regulation of glucose transporter ptsG mRNA stability in response to a metabolic stress.
      Title: Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli.
    4. Enolase is recruited into putative RNA degradosome machinery in these bacilli, where it plays common regulatory functions.
      Title: Recognition of enolase in the Escherichia coli RNA degradosome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopyruvate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopyruvate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA processing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of bacterial degradosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphopyruvate hydratase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    enolase
    NP_417259.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2906643..2907941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417259.1 enolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417259.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AQ60
      Conserved Domains (1) summary
      PRK00077
      Location:1 → 432
      eno; enolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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