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    mtlD mannitol-1-phosphate 5-dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948117, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mtlD
    Official Full Name
    mannitol-1-phosphate 5-dehydrogenase
    Primary source
    ECOCYC:EG10616
    Locus tag
    b3600
    See related
    ASAP:ABE-0011767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3589
    Summary
    The protein has been purified as both a monomer and an apparent dimer. [More information is available at EcoCyc: EG10616].
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    Genomic context

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    Sequence:
    NC_000913.3 (3774424..3775572)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF3302 domain-containing protein YibI Neighboring gene mannitol-specific PTS enzyme IICBA component Neighboring gene transcriptional repressor MtlR Neighboring gene protein YibT Neighboring gene DUF2810 domain-containing protein YibL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid turnover of mannitol-1-phosphate in Escherichia coli. Rosenberg H, et al. J Bacteriol, 1984 Apr. PMID 6425270, Free PMC Article
    2. Enzymatic properties, renaturation and metabolic role of mannitol-1-phosphate dehydrogenase from Escherichia coli. Teschner W, et al. Biochimie, 1990 Jan. PMID 2111176
    3. Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli. Novotny MJ, et al. J Bacteriol, 1984 Sep. PMID 6384188, Free PMC Article
    4. Mutations affecting the dissimilation of mannitol by Escherichia coli K-12. Solomon E, et al. J Bacteriol, 1972 Aug. PMID 4559737, Free PMC Article
    5. Nucleotide sequence of the mannitol (mtl) operon in Escherichia coli. Davis T, et al. Mol Microbiol, 1988 May. PMID 3135464

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables mannitol-1-phosphate 5-dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannitol-1-phosphate 5-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannitol-1-phosphate 5-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mannitol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mannitol catabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within mannitol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannitol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mannitol-1-phosphate 5-dehydrogenase
    NP_418057.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3774424..3775572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418057.1 mannitol-1-phosphate 5-dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418057.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0S2I9Z3, B1A9U1, Q0PWM5
      Conserved Domains (1) summary
      PRK02318
      Location:1 → 382
      PRK02318; mannitol-1-phosphate 5-dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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