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    gldA L-1,2-propanediol dehydrogenase/glycerol dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948440, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gldA
    Official Full Name
    L-1,2-propanediol dehydrogenase/glycerol dehydrogenase
    Primary source
    ECOCYC:EG11904
    Locus tag
    b3945
    See related
    ASAP:ABE-0012912
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3937
    Summary
    The enzyme is found in two catalytically active forms, a large form of eight subunits and a small form of two subunits. [More information is available at EcoCyc: EG11904].
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    Genomic context

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    Sequence:
    NC_000913.3 (4137932..4139035, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cystine exporter Neighboring gene DUF1287 domain-containing protein YijF Neighboring gene fructose-6-phosphate aldolase 2 Neighboring gene putative PTS multiphosphoryl transfer protein PtsA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formation of D-1-amino-2-propanol from L-threonine by enzymes from Escherichia coli K-12. Campbell RL, et al. Biochem Biophys Res Commun, 1973 Jul 17. PMID 4577583
    2. Derepression of an NAD-linked dehydrogenase that serves an Escherichia coli mutant for growth on glycerol. Tang JC, et al. J Bacteriol, 1982 Dec. PMID 6754692, Free PMC Article
    3. Structure of glycerol dehydrogenase (GldA) from Escherichia coli. Zhang J, et al. Acta Crystallogr F Struct Biol Commun, 2019 Mar 1. PMID 30839292, Free PMC Article
    4. A glycerol dehydrogenase from Escherichia coli. ASNIS RE, et al. J Biol Chem, 1953 Jul. PMID 13069498
    5. D-1-amino-2-propanol:NAD+ oxidoreductase. Purification and general properties of the large molecular form of the enzyme from Escherichia coli K12. Kelley JJ, et al. J Biol Chem, 1984 Feb 25. PMID 6365902

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study proposes that the primary role of gldA is to remove toxic dihydroxyacetone by converting it into glycerol.
      Title: Role of GldA in dihydroxyacetone and methylglyoxal metabolism of Escherichia coli K12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables (R)-aminopropanol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (R)-aminopropanol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaerobic glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within anaerobic glycerol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylglyoxal catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-1,2-propanediol dehydrogenase/glycerol dehydrogenase
    NP_418380.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4137932..4139035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418380.4 L-1,2-propanediol dehydrogenase/glycerol dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418380.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CG58, A0A1X3J9V3, A0AA36P881, A0AAN3SDD8, F4T6I3
      Conserved Domains (1) summary
      PRK09423
      Location:1 → 366
      gldA; glycerol dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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