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    fimE regulator for fimA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948836, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fimE
    Official Full Name
    regulator for fimA
    Primary source
    ECOCYC:EG10312
    Locus tag
    b4313
    See related
    ASAP:ABE-0014143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4304; hyp; pilH
    Summary
    FimE forms a transient covalent Tyr linkage to DNA. [More information is available at EcoGene: EG10312]. FimE, along with FimB, is a recombinase in Escherichia coli which catalyzes the site-specific recombination required for inversion of a 314-bp invertible DNA element, the fim switch (fimS), to control transcription of the type I fimbrial structural genes--a process known as phase-variation switching. fimS contains the promoter for expression of the fimbrial structural genes. [More information is available at EcoCyc: EG10312].
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    Genomic context

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    Sequence:
    NC_000913.3 (4542037..4542633)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate outer membrane channel Neighboring gene Type 1 fimbriae regulatory protein FimB Neighboring gene type 1 fimbriae major subunit Neighboring gene putative fimbrial protein FimI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exact solution of a model DNA-inversion genetic switch with orientational control. Visco P, et al. Phys Rev Lett, 2008 Sep 12. PMID 18851337
    2. Type 1 fimbriation and fimE mutants of Escherichia coli K-12. Blomfield IC, et al. J Bacteriol, 1991 Sep. PMID 1679429, Free PMC Article
    3. Orientational control of fimE expression in Escherichia coli. Sohanpal BK, et al. Mol Microbiol, 2001 Oct. PMID 11703669
    4. Modulation of Escherichia coli type 1 fimbrial expression and adherence to uroepithelial cells following exposure of logarithmic phase cells to quinolones at subinhibitory concentrations. Breines DM, et al. J Antimicrob Chemother, 1994 Aug. PMID 7814281
    5. Functional analysis of the FimE integrase of Escherichia coli K-12: isolation of mutant derivatives with altered DNA inversion preferences. Smith SG, et al. Mol Microbiol, 1999 Dec. PMID 10594822

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FimB inverts the switch in the ON-to-OFF and OFF-to-ON directions with similar efficiencies, whereas FimE inverts it predominantly in the ON-to-OFF direction.
      Title: DNA sequence heterogeneity in Fim tyrosine-integrase recombinase-binding elements and functional motif asymmetries determine the directionality of the fim genetic switch in Escherichia coli K-12.
    2. By controlling transcription and ratio of fimB and fimE, RcsB regulates type 1 piliation.
      Title: The two-component response regulator RcsB regulates type 1 piliation in Escherichia coli.
    3. The data support a model in which the FimB and FimE recombinases differ in loading order and co-operative interactions. PapB exploits this difference and FimE becomes susceptible when its normal loading is restricted or changed.
      Title: Comparative analysis of FimB and FimE recombinase activity.
    4. findings show that transcription termination of fimE is Rho dependent and is suppressed in a rho mutant or by bicyclomycin treatment when fimE mRNA is expressed by the fimE gene, either from a recombinant plasmid or in its native chromosomal location
      Title: Characterization of the detachable Rho-dependent transcription terminator of the fimE gene in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tyrosine-based site-specific recombinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA integration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of DNA recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    regulator for fimA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4542037..4542633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418733.1 regulator for fimA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418733.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0S2ZYI3, A0A0S2ZZ78, A0A1V2GLG7, A0A828PLL9
      Conserved Domains (1) summary
      PRK09871
      Location:1 → 198
      PRK09871; tyrosine recombinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials