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    symE nucleoid-associated protein SymE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949088, updated on 3-Dec-2024

    Summary

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    Official Symbol
    symE
    Official Full Name
    nucleoid-associated protein SymE
    Primary source
    ECOCYC:G7940
    Locus tag
    b4347
    See related
    ASAP:ABE-0014253
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dinL; ECK4337; sosC; yjiW
    Summary
    SymE is toxic when overexpressed which leads to inhibition of protein synthesis and RNA degradation (Kawano, 2007). [More information is available at EcoGene: EG12584]. SymE belongs to the AbrB superfamily of proteins, which also contains the antitoxin MazE. [More information is available at EcoCyc: G7940].
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    Genomic context

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    Sequence:
    NC_000913.3 (4579499..4579840, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Type IV methyl-directed restriction enzyme EcoKMcrBC subunit Neighboring gene 5-methylcytosine-specific restriction enzyme subunit McrB;McrBS Neighboring gene ncRNA Neighboring gene type I restriction enzyme EcoKI specificity subunit Neighboring gene type I restriction enzyme EcoKI methylase subunit Neighboring gene type I restriction enzyme EcoKI endonuclease subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Escherichia coli SymE is a DNA-binding protein that can condense the nucleoid. Thompson MK, et al. Mol Microbiol, 2022 Apr. PMID 34964191, Free PMC Article
    2. Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli. Lewis LK, et al. J Mol Biol, 1994 Aug 26. PMID 8057377
    3. Detection of 5'- and 3'-UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli. Kawano M, et al. Nucleic Acids Res, 2005. PMID 15718303, Free PMC Article
    4. Identification of additional genes belonging to the LexA regulon in Escherichia coli. Fernández De Henestrosa AR, et al. Mol Microbiol, 2000 Mar. PMID 10760155
    5. Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks. Rooney JP, et al. Genomics, 2009 Jan. PMID 18824089, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Escherichia coli SymE is a DNA-binding protein that can condense the nucleoid.
      Title: Escherichia coli SymE is a DNA-binding protein that can condense the nucleoid.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within SOS response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in bacterial nucleoid packaging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleoid organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with bacterial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in bacterial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleoid-associated protein SymE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4579499..4579840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418767.4 nucleoid-associated protein SymE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418767.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GEX0
      Conserved Domains (1) summary
      PRK13605
      Location:1 → 113
      PRK13605; endoribonuclease SymE; Provisional
    Nucleotide Protein
    Heading Accession and Version

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