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    ribF bifunctional riboflavin kinase/FMN adenylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949129, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ribF
    Official Full Name
    bifunctional riboflavin kinase/FMN adenylyltransferase
    Primary source
    ECOCYC:EG11079
    Locus tag
    b0025
    See related
    ASAP:ABE-0000091
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0026; yaaC
    Summary
    The riboflavin kinase is the N-terminal domain; the FAD synthase is the C-terminal domain. [More information is available at EcoGene: EG11079]. It is thought that ribF encodes a bifunctional protein with riboflavin kinase and FMN adenylyltransferase activities. [More information is available at EcoCyc: EG11079].
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    Genomic context

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    Sequence:
    NC_000913.3 (21407..22348)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit protein S20 Neighboring gene DUF2575 domain-containing protein YaaY Neighboring gene isoleucine--tRNA ligase Neighboring gene lipoprotein signal peptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the genes in the Escherichia coli ileS-lsp operon. Analysis of multiple polycistronic mRNAs made in vivo. Miller KW, et al. J Biol Chem, 1987 May 25. PMID 3294831
    2. Cotranscription of the Escherichia coli isoleucyl-tRNA synthetase (ileS) and prolipoprotein signal peptidase (lsp) genes. Fine-structure mapping of the lsp internal promoter. Miller KW, et al. J Biol Chem, 1987 Jan 5. PMID 2432063
    3. Characterization of the ileS-lsp operon in Escherichia coli. Identification of an open reading frame upstream of the ileS gene and potential promoter(s) for the ileS-lsp operon. Kamio Y, et al. J Biol Chem, 1985 May 10. PMID 2985604
    4. From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways. Gerdes SY, et al. J Bacteriol, 2002 Aug. PMID 12142426, Free PMC Article
    5. A genome-based approach for the identification of essential bacterial genes. Arigoni F, et al. Nat Biotechnol, 1998 Sep. PMID 9743119

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN adenylyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables riboflavin kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables riboflavin kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FMN biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in FMN biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional riboflavin kinase/FMN adenylyltransferase
    NP_414566.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      21407..22348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414566.1 bifunctional riboflavin kinase/FMN adenylyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414566.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A836NFS5, A0A8E0FJP9, A0AAN3V3K0, A0AAN4NXY0, A0AAV3H188, A0AAV3IC31
      Conserved Domains (1) summary
      PRK05627
      Location:2 → 309
      PRK05627; bifunctional riboflavin kinase/FAD synthetase
    Nucleotide Protein
    Heading Accession and Version

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