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    ftsL cell division protein FtsL [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944803, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ftsL
    Official Full Name
    cell division protein FtsL
    Primary source
    ECOCYC:EG11086
    Locus tag
    b0083
    See related
    ASAP:ABE-0000306
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0084; mraR; yabD
    Summary
    The ftsL gene is essential. [More information is available at EcoGene: EG11086]. FtsL is essential for growth and cell division; the protein is present in very small amounts of approximately 25 molecules per cell . [More information is available at EcoCyc: EG11086].
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    Genomic context

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    Sequence:
    NC_000913.3 (91032..91397)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator Cra Neighboring gene DNA-binding transcriptional repressor MraZ Neighboring gene 16S rRNA m(4)C1402 methyltransferase Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene ncRNA Neighboring gene UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Neighboring gene D-alanyl-D-alanine-adding enzyme

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell division in Escherichia coli: role of FtsL domains in septal localization, function, and oligomerization. Ghigo JM, et al. J Bacteriol, 2000 Jan. PMID 10613870, Free PMC Article
    2. New mutations fts-36, lts-33, and ftsW clustered in the mra region of the Escherichia coli chromosome induce thermosensitive cell growth and division. Ishino F, et al. J Bacteriol, 1989 Oct. PMID 2676977, Free PMC Article
    3. Identification of a novel function for the FtsL cell division protein from Escherichia coli K12. Blencowe DK, et al. Biochem Biophys Res Commun, 2011 Jul 22. PMID 21708137
    4. The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions. Condon SGF, et al. J Biol Chem, 2018 Feb 2. PMID 29233891, Free PMC Article
    5. Bacterial cytokinesis: From Z ring to divisome. Lutkenhaus J, et al. Cytoskeleton (Hoboken), 2012 Oct. PMID 22888013, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
      Title: The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
    2. Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
      Title: Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
    3. The authors discovered that FtsBLQ inhibits the glycosyltransferase activity of PBP1b and that this inhibition was antagonized by the PBP1b activators FtsN and LpoB.
      Title: Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN.
    4. the data suggest that FtsL forms an uninterrupted helix across the two regions and that the integrity of this helix is indispensable for the function of the complex. The FtsL helix is thus a candidate for acting as a potential mechanical connection to communicate conformational changes between periplasmic, membrane, and cytoplasmic regions.
      Title: The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions.
    5. results support a model in which FtsL, along with its partners FtsB and FtsQ, function as part of a sensing mechanism that promotes the onset of cell wall remodeling processes.
      Title: A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division.
    6. A structural model was developed for the periplasmic part of the FtsB/FtsL/FtsQ complex.
      Title: A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.
    7. The authors demonstrate that the leucine zipper-like (LZ) motifs, located in the periplasmic domain of FtsL and FtsB, are required for an optimal interaction between these two essential proteins.
      Title: Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB.
    8. ftsL can confer a metal-ion sensitive phenotype and trans-membrane cysteine residues play a role in FtsL function in elevated metal-ion concentrations.
      Title: Identification of a novel function for the FtsL cell division protein from Escherichia coli K12.
    9. Study find that, as with FtsB, the C terminus of FtsL is required for the interaction of FtsQ with the FtsB/FtsL subcomplex while the cytoplasmic domain of FtsL is involved in recruitment of the downstream division proteins.
      Title: Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.
    10. FtsL is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins.
      Title: Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in FtsZ-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in FtsZ-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in division septum assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FtsBL complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of FtsQBL complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell division site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell division site NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of divisome complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of divisome complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division protein FtsL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      91032..91397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414625.1 cell division protein FtsL [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414625.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MCK7
      Conserved Domains (1) summary
      PRK10772
      Location:17 → 121
      PRK10772; cell division protein FtsL; Provisional
    Nucleotide Protein
    Heading Accession and Version

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