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    ftsW peptidoglycan glycosyltransferase FtsW [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946322, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ftsW
    Official Full Name
    peptidoglycan glycosyltransferase FtsW
    Primary source
    ECOCYC:EG10344
    Locus tag
    b0089
    See related
    ASAP:ABE-0000320
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0090
    Summary
    FtsW is required for mrdA(PBP2) expression. ftsW is paralogous to mrdB(rodA). ftsW is an essential gene. [More information is available at EcoGene: EG10344]. FtsW is an essential cell division protein that is conserved in most walled bacteria; the protein is produced at low levels and localizes to the septum . [More information is available at EcoCyc: EG10344].
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    Genomic context

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    Sequence:
    NC_000913.3 (98403..99647)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-alanyl-D-alanine-adding enzyme Neighboring gene phospho-N-acetylmuramoyl-pentapeptide-transferase Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene N-acetylglucosaminyl transferase Neighboring gene UDP-N-acetylmuramate--L-alanine ligase Neighboring gene D-alanine--D-alanine ligase B Neighboring gene cell division protein FtsQ Neighboring gene cell division protein FtsA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW. Yang X, et al. Nat Microbiol, 2021 May. PMID 33495624, Free PMC Article
    2. ftsW is an essential cell-division gene in Escherichia coli. Boyle DS, et al. Mol Microbiol, 1997 Jun. PMID 9218774
    3. Topological characterization of the essential Escherichia coli cell division protein FtsW. Lara B, et al. FEMS Microbiol Lett, 2002 Oct 29. PMID 12423747
    4. Two polypeptide products of the Escherichia coli cell division gene ftsW and a possible role for FtsW in FtsZ function. Khattar MM, et al. J Bacteriol, 1997 Feb. PMID 9006034, Free PMC Article
    5. Identification of FtsW and characterization of a new ftsW division mutant of Escherichia coli. Khattar MM, et al. J Bacteriol, 1994 Dec. PMID 7961485, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW.
      Title: A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW.
    2. Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
      Title: Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
    3. Data show that the transmembrane helix 4 of membrane protein FtsW is required for the transport activity of the protein.
      Title: Specificity of the transport of lipid II by FtsW in Escherichia coli.
    4. In this work the authors show direct interactions between FtsW and PBP3 in vivo and in vitro by FRET (Forster resonance energy transfer) and co-immunoprecipitation experiments.
      Title: The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex in Escherichia coli.
    5. Data show that FtsW interact with MtgA and help MtgA's role in peptidoglycan assembly during the cell cycle.
      Title: The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.
    6. FtsW is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins.
      Title: Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
    7. identification of several domains of the protein with distinct functions in cell division
      Title: Functional analysis of the cell division protein FtsW of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid-linked peptidoglycan transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid-linked peptidoglycan transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FtsZ-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in division septum assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in lipid-linked peptidoglycan transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell division site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell division site NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of divisome complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan glycosyltransferase FtsW

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      98403..99647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414631.1 peptidoglycan glycosyltransferase FtsW [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414631.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CI42, A0AA36P079, Q1RGA6
      Conserved Domains (1) summary
      PRK10774
      Location:11 → 414
      PRK10774; cell division protein FtsW; Provisional
    Nucleotide Protein
    Heading Accession and Version

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