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    yacG DNA gyrase inhibitor YacG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945630, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yacG
    Official Full Name
    DNA gyrase inhibitor YacG
    Primary source
    ECOCYC:EG12314
    Locus tag
    b0101
    See related
    ASAP:ABE-0000351
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0101
    Summary
    YacG binds the C-terminal domain of GyrB, inhibiting its activity by blocking its binding to DNA (Sengupta, 2008). [More information is available at EcoGene: EG12314]. DNA gyrase inhibitor YacG blocks DNA binding by DNA gyrase, inhibiting its function. [More information is available at EcoCyc: EG12314].
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    Genomic context

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    Sequence:
    NC_000913.3 (111649..111846, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein translocation ATPase Neighboring gene 8-oxo-dGTP diphosphatase Neighboring gene cell division factor ZapD Neighboring gene dephospho-CoA kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that causes A:T to C:G transversion. Akiyama M, et al. Mol Gen Genet, 1987 Jan. PMID 3033442
    2. Reliable identification of protein-protein interactions by crosslinking mass spectrometry. Lenz S, et al. Nat Commun, 2021 Jun 11. PMID 34117231, Free PMC Article
    3. Tools for characterization of Escherichia coli genes of unknown function. Merlin C, et al. J Bacteriol, 2002 Aug. PMID 12142427, Free PMC Article
    4. Genetic footprinting in bacteria. Hare RS, et al. J Bacteriol, 2001 Mar. PMID 11160101, Free PMC Article
    5. A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Zaslaver A, et al. Nat Methods, 2006 Aug. PMID 16862137

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA gyrase inhibitor YacG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      111649..111846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414643.1 DNA gyrase inhibitor YacG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414643.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JIS6
      Conserved Domains (1) summary
      PRK00418
      Location:1 → 62
      PRK00418; DNA gyrase inhibitor YacG
    Nucleotide Protein
    Heading Accession and Version

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