U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    acnB AcnB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944864, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    acnB
    Official Full Name
    AcnB
    Primary source
    ECOCYC:EG12316
    Locus tag
    b0118
    See related
    ASAP:ABE-0000411
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0117; yacI; yacJ
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG12316]. Purification of the enzyme is described . [More information is available at EcoCyc: EG12316].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (131615..134212)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoamide dehydrogenase Neighboring gene DUF3300 domain-containing protein YacH Neighboring gene PF06062 family protein YacL Neighboring gene S-adenosylmethionine decarboxylase proenzyme

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The iron-sensing aconitase B binds its own mRNA to prevent sRNA-induced mRNA cleavage. Benjamin JA, et al. Nucleic Acids Res, 2014 Sep. PMID 25092924, Free PMC Article
    2. Switching aconitase B between catalytic and regulatory modes involves iron-dependent dimer formation. Tang Y, et al. Mol Microbiol, 2005 Jun. PMID 15882410
    3. E. coli aconitase B structure reveals a HEAT-like domain with implications for protein-protein recognition. Williams CH, et al. Nat Struct Biol, 2002 Jun. PMID 11992126
    4. Cooperativity of two active sites in bacterial homodimeric aconitases. Tsuchiya D, et al. Biochem Biophys Res Commun, 2009 Feb 6. PMID 19116142
    5. Versatile architecture of a bacterial aconitase B and its catalytic performance in the sequential reaction coupled with isocitrate dehydrogenase. Tsuchiya D, et al. Biochim Biophys Acta, 2008 Nov. PMID 18640291

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest that apo-AcnB protects acnB mRNA from RNase E-mediated cleavage after RyhB pairing.
      Title: The iron-sensing aconitase B binds its own mRNA to prevent sRNA-induced mRNA cleavage.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    3. the N-terminal region of AcnB is necessary and sufficient for promoting the formation of AcnB dimers and also for AcnB binding to target mRNA
      Title: Switching aconitase B between catalytic and regulatory modes involves iron-dependent dimer formation.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-methylisocitrate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-methylisocitrate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-methylisocitrate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glyoxylate cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in propionate catabolic process, 2-methylcitrate cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within propionate catabolic process, 2-methylcitrate cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    AcnB
    NP_414660.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      131615..134212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414660.1 AcnB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414660.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GEN7
      Conserved Domains (1) summary
      PRK09238
      Location:1 → 846
      PRK09238; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.