panB 3-methyl-2-oxobutanoate hydroxymethyltransferase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: panB
Official Full Name: 3-methyl-2-oxobutanoate hydroxymethyltransferase
Primary source: ECOCYC:EG11675
Locus tag: b0134
See related: ASAP:ABE-0000467
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0133
Summary: 3-methyl-2-oxobutanoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step of the pantothenate biosynthesis pathway, transferring the C11 carbon of 5,10-methylene-tetrahydrofolate onto 2-keto-isovalerate to form 2-dehydropantoate . [More information is available at EcoCyc: EG11675].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

N-terminus verified by Edman degradation on complete protein
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pantothenate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pantothenate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pantothenate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed

NP_414676.1

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The following sections contain reference sequences that belong to a specific genome build. Explain