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    queC 7-cyano-7-deazaguanine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947034, updated on 3-Dec-2024

    Summary

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    Official Symbol
    queC
    Official Full Name
    7-cyano-7-deazaguanine synthase
    Primary source
    ECOCYC:G6245
    Locus tag
    b0444
    See related
    ASAP:ABE-0001539
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0438; ybaX
    Summary
    Asn, Asp, Tyr, and His tRNA anticodons are modified. [More information is available at EcoGene: EG13252]. QueC catalyzes an early step of queuosine biosynthesis, in the step(s) leading from GTP to the formation of preQ0 . [More information is available at EcoCyc: G6245].
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    Genomic context

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    Sequence:
    NC_000913.3 (464852..465547, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene helix-hairpin-helix 3 family protein Neighboring gene long-chain acyl-CoA thioesterase FadM Neighboring gene uncharacterized protein YbaE Neighboring gene HMP-PP phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting QseC signaling and virulence for antibiotic development. Rasko DA, et al. Science, 2008 Aug 22. PMID 18719281, Free PMC Article
    2. An unexpected absence of queuosine modification in the tRNAs of an Escherichia coli B strain. Dineshkumar TK, et al. Microbiology (Reading), 2002 Dec. PMID 12480882
    3. Possible anticodon sequences of tRNA His , tRNA Asm , and tRNA Asp from Escherichia coli B. Universal presence of nucleoside Q in the first postion of the anticondons of these transfer ribonucleic acids. Harada F, et al. Biochemistry, 1972 Jan 18. PMID 4550561
    4. Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Kasai H, et al. Biochemistry, 1975 Sep 23. PMID 1101947
    5. Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA. Yokoyama S, et al. Nature, 1979 Nov 1. PMID 388227

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. genetic analysis to identify queC (ybaX) as a new member of the queuosine biosynthetic pathway whose gene product is essential in biosynthesis of preQ0
      Title: Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity, forming carbon-nitrogen bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within queuosine biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in queuosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    7-cyano-7-deazaguanine synthase
    NP_414978.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      464852..465547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414978.1 7-cyano-7-deazaguanine synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414978.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7BH25
      Conserved Domains (1) summary
      PRK11106
      Location:1 → 231
      PRK11106; queuosine biosynthesis protein QueC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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