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    ybaZ DNA base-flipping protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945094, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ybaZ
    Official Full Name
    DNA base-flipping protein
    Primary source
    ECOCYC:G6251
    Locus tag
    b0454
    See related
    ASAP:ABE-0001576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    atl; ECK0448
    Summary
    YbaZ is homologous to methylated-DNA--protein-cysteine methyltransferases Ada and Ogt, but lacks the active site cysteine. [More information is available at EcoGene: EG13254]. YbaZ (Atl) binds to double-stranded DNA with an abasic site and acts as a base-flipping protein. [More information is available at EcoCyc: G6251].
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    Genomic context

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    Sequence:
    NC_000913.3 (475982..476371, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase II Neighboring gene PF09619 family lipoprotein YbaY Neighboring gene ncRNA Neighboring gene DUF1428 domain-containing protein YbaA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alkyltransferase-like proteins. Margison GP, et al. DNA Repair (Amst), 2007 Aug 1. PMID 17500045
    2. Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli. Pearson SJ, et al. Nucleic Acids Res, 2005. PMID 16027108, Free PMC Article
    3. The alkyltransferase-like ybaZ gene product enhances nucleotide excision repair of O(6)-alkylguanine adducts in E. coli. Mazon G, et al. DNA Repair (Amst), 2009 Jun 4. PMID 19269902
    4. A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli. Chen CS, et al. Nat Methods, 2008 Jan. PMID 18084297, Free PMC Article
    5. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    DNA base-flipping protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      475982..476371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414988.1 DNA base-flipping protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414988.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2YWD1, A0A1Q6AMN5, A0A1Q6B4Y7, A0A2A2XJE5, A0A2D0CVT9, A0A2S5RTS6, A0A5R8RFJ2, A0A7B3MIA9, A0AAD2RZD9, B7MDX6, B7MQH0, B7UKD6, C3TLJ7, F4SUS3, J7Q6D7
      Conserved Domains (1) summary
      COG3695
      Location:27 → 129
      Atl1; Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain [Transcription]
    Nucleotide Protein
    Heading Accession and Version

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