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    fsr fosmidomycin efflux pump [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945119, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fsr
    Official Full Name
    fosmidomycin efflux pump
    Primary source
    ECOCYC:G6256
    Locus tag
    b0479
    See related
    ASAP:ABE-0001661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0473
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG13268]. Fsr is a putative fosmidomycin efflux protein. [More information is available at EcoCyc: G6256].
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    Genomic context

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    Sequence:
    NC_000913.3 (503476..504696, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inosine/guanosine kinase Neighboring gene putative transporter YbaL Neighboring gene 5'-nucleotidase/UDP-sugar hydrolase Neighboring gene Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification. Fujisaki S, et al. Gene, 1996 Oct 10. PMID 8917080
    2. Analysis of a complete library of putative drug transporter genes in Escherichia coli. Nishino K, et al. J Bacteriol, 2001 Oct. PMID 11566977, Free PMC Article
    3. Microbial drug efflux proteins of the major facilitator superfamily. Saidijam M, et al. Curr Drug Targets, 2006 Jul. PMID 16842212
    4. The major facilitator superfamily. Saier MH Jr, et al. J Mol Microbiol Biotechnol, 1999 Nov. PMID 10943556
    5. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Marger MD, et al. Trends Biochem Sci, 1993 Jan. PMID 8438231

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fosmidomycin efflux pump

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      503476..504696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415012.1 fosmidomycin efflux pump [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415012.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FQ19, A0A8T5YLQ4
      Conserved Domains (1) summary
      cd17478
      Location:30 → 398
      MFS_FsR; Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version

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