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    bioA adenosylmethionine-8-amino-7-oxononanoate aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945376, updated on 3-Dec-2024

    Summary

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    Official Symbol
    bioA
    Official Full Name
    adenosylmethionine-8-amino-7-oxononanoate aminotransferase
    Primary source
    ECOCYC:EG10117
    Locus tag
    b0774
    See related
    ASAP:ABE-0002635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0763
    Summary
    bioA encodes the 7,8-diaminopelargonic acid synthase enzyme in the biotin biosynthesis pathway. [More information is available at EcoCyc: EG10117].
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    Genomic context

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    Sequence:
    NC_000913.3 (807968..809257, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane lipoprotein YbhC Neighboring gene putative kinase inhibitor Neighboring gene biotin synthase Neighboring gene 8-amino-7-oxononanoate synthase Neighboring gene malonyl-acyl carrier protein methyltransferase Neighboring gene dethiobiotin synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The isolation and identification of 7-oxo-8-aminopelargonic acid, a biotin intermediate. Eisenberg MA, et al. Biochemistry, 1970 Jan 6. PMID 5411202
    2. 7,8-Diaminopelargonic acid aminotransferase. Eisenberg MA, et al. Methods Enzymol, 1979. PMID 374976
    3. Active transport of biotin in Escherichia coli K-12. Prakash O, et al. J Bacteriol, 1974 Nov. PMID 4616949, Free PMC Article
    4. Inhibition of 7,8-diaminopelargonic acid aminotransferase by amiclenomycin and analogues. Mann S, et al. Biochem Soc Trans, 2005 Aug. PMID 16042602
    5. Conserved and nonconserved residues in the substrate binding site of 7,8-diaminopelargonic acid synthase from Escherichia coli are essential for catalysis. Sandmark J, et al. Biochemistry, 2004 Feb 10. PMID 14756557

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biotin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biotin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenosylmethionine-8-amino-7-oxononanoate aminotransferase
    NP_415295.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      807968..809257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415295.1 adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415295.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FQ28
      Conserved Domains (1) summary
      PRK07986
      Location:1 → 428
      PRK07986; adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated
    Nucleotide Protein
    Heading Accession and Version

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