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    dgcJ diguanylate cyclase DgcJ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946290, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dgcJ
    Official Full Name
    diguanylate cyclase DgcJ
    Primary source
    ECOCYC:G6972
    Locus tag
    b1786
    See related
    ASAP:ABE-0005943
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1784; yeaJ
    Summary
    A yeaJ null mutation partially suppresses the motility defect of a yhjH mutation at 37C; a yegE null mutation is a better yhjH suppressor at 28C; full yhjH suppression requires yegE, yedQ and yeaJ null mutations when grown at 37C (Pesavento, 2008). [More information is available at EcoGene: EG13496].
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    Genomic context

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    Sequence:
    NC_000913.3 (1872041..1873531)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF444 domain-containing protein YeaH Neighboring gene putative c-di-GMP binding protein CdgI Neighboring gene mischarged aminoacyl-tRNA deacylase Neighboring gene protein YoaI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bacterial nucleotide-based second messengers. Pesavento C, et al. Curr Opin Microbiol, 2009 Apr. PMID 19318291
    2. GGDEF proteins YeaI, YedQ, and YfiN reduce early biofilm formation and swimming motility in Escherichia coli. Sanchez-Torres V, et al. Appl Microbiol Biotechnol, 2011 Apr. PMID 21181144, Free PMC Article
    3. Transcriptional responses of Escherichia coli to S-nitrosoglutathione under defined chemostat conditions reveal major changes in methionine biosynthesis. Flatley J, et al. J Biol Chem, 2005 Mar 18. PMID 15647275
    4. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609
    5. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables diguanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diguanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of bacterial-type flagellum-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diguanylate cyclase DgcJ
    NP_416300.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1872041..1873531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416300.2 diguanylate cyclase DgcJ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416300.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WUY5
      Conserved Domains (2) summary
      pfam17155
      Location:31 → 304
      GAPES1; Gammaproteobacterial periplasmic sensor domain
      pfam00990
      Location:347 → 495
      GGDEF; Diguanylate cyclase, GGDEF domain
    Nucleotide Protein
    Heading Accession and Version

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